Cargando…
Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy
In this study, we investigated the variability of vascular hysteresis loop (VHL) shapes and the spatial heterogeneity of neovascularization and microvascular alterations using vascular architecture mapping (VAM) in patients with recurrent glioblastoma during bevacizumab mono-therapy. VAM data were a...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561153/ https://www.ncbi.nlm.nih.gov/pubmed/28819189 http://dx.doi.org/10.1038/s41598-017-09048-w |
_version_ | 1783257787625635840 |
---|---|
author | Stadlbauer, Andreas Zimmermann, Max Oberndorfer, Stefan Doerfler, Arnd Buchfelder, Michael Heinz, Gertraud Roessler, Karl |
author_facet | Stadlbauer, Andreas Zimmermann, Max Oberndorfer, Stefan Doerfler, Arnd Buchfelder, Michael Heinz, Gertraud Roessler, Karl |
author_sort | Stadlbauer, Andreas |
collection | PubMed |
description | In this study, we investigated the variability of vascular hysteresis loop (VHL) shapes and the spatial heterogeneity of neovascularization and microvascular alterations using vascular architecture mapping (VAM) in patients with recurrent glioblastoma during bevacizumab mono-therapy. VAM data were acquired in 13 patients suffering from recurrent glioblastoma prior to and 3 months after bevacizumab treatment onset using a dual contrast agent injections approach as part of routine MRI. Two patients were additionally examined after the first cycle of bevacizumab to check for early treatment response. VHLs were evaluated as biomarker maps of neovascularization activity: microvessel type indicator (MTI) and curvature (Curv) of the VHL-long-axis. Early response to bevacizumab was dominated by reduction of smaller microvasculature (around 10 µm). In the 3-month follow-up, responding tumors additionally showed a reduction in larger microvasculature (>20 µm). VAM biomarker images revealed spatially heterogeneous microvascular alterations during bevacizumab treatment. Responding, non-responding, progressive, and remote-progressive tumor areas were observed. MTI may be useful to predict responding and non-responding tumor regions, and Curv to assess severity of vasogenic edema. Analysis of VHLs in combination with VAM biomarkers may lead to a new perspective on investigating the spatial heterogeneity of neovascularization and microvascular alterations in glioblastoma during antiangiogenic therapy. |
format | Online Article Text |
id | pubmed-5561153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55611532017-08-18 Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy Stadlbauer, Andreas Zimmermann, Max Oberndorfer, Stefan Doerfler, Arnd Buchfelder, Michael Heinz, Gertraud Roessler, Karl Sci Rep Article In this study, we investigated the variability of vascular hysteresis loop (VHL) shapes and the spatial heterogeneity of neovascularization and microvascular alterations using vascular architecture mapping (VAM) in patients with recurrent glioblastoma during bevacizumab mono-therapy. VAM data were acquired in 13 patients suffering from recurrent glioblastoma prior to and 3 months after bevacizumab treatment onset using a dual contrast agent injections approach as part of routine MRI. Two patients were additionally examined after the first cycle of bevacizumab to check for early treatment response. VHLs were evaluated as biomarker maps of neovascularization activity: microvessel type indicator (MTI) and curvature (Curv) of the VHL-long-axis. Early response to bevacizumab was dominated by reduction of smaller microvasculature (around 10 µm). In the 3-month follow-up, responding tumors additionally showed a reduction in larger microvasculature (>20 µm). VAM biomarker images revealed spatially heterogeneous microvascular alterations during bevacizumab treatment. Responding, non-responding, progressive, and remote-progressive tumor areas were observed. MTI may be useful to predict responding and non-responding tumor regions, and Curv to assess severity of vasogenic edema. Analysis of VHLs in combination with VAM biomarkers may lead to a new perspective on investigating the spatial heterogeneity of neovascularization and microvascular alterations in glioblastoma during antiangiogenic therapy. Nature Publishing Group UK 2017-08-17 /pmc/articles/PMC5561153/ /pubmed/28819189 http://dx.doi.org/10.1038/s41598-017-09048-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Stadlbauer, Andreas Zimmermann, Max Oberndorfer, Stefan Doerfler, Arnd Buchfelder, Michael Heinz, Gertraud Roessler, Karl Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy |
title | Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy |
title_full | Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy |
title_fullStr | Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy |
title_full_unstemmed | Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy |
title_short | Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy |
title_sort | vascular hysteresis loops and vascular architecture mapping in patients with glioblastoma treated with antiangiogenic therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561153/ https://www.ncbi.nlm.nih.gov/pubmed/28819189 http://dx.doi.org/10.1038/s41598-017-09048-w |
work_keys_str_mv | AT stadlbauerandreas vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy AT zimmermannmax vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy AT oberndorferstefan vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy AT doerflerarnd vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy AT buchfeldermichael vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy AT heinzgertraud vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy AT roesslerkarl vascularhysteresisloopsandvasculararchitecturemappinginpatientswithglioblastomatreatedwithantiangiogenictherapy |