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Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model

The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and i...

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Autores principales: Pierzynowski, Stefan G., Goncharova, Kateryna, Gregory, Peter C., Weström, Björn, Podpryatov, Sergiy E., Podpriatov, Sergii S., Woliński, Jarosław, Repich, Hlib, Wierup, Nils, Lozinska, Liudmyla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561192/
https://www.ncbi.nlm.nih.gov/pubmed/28819193
http://dx.doi.org/10.1038/s41598-017-07387-2
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author Pierzynowski, Stefan G.
Goncharova, Kateryna
Gregory, Peter C.
Weström, Björn
Podpryatov, Sergiy E.
Podpriatov, Sergii S.
Woliński, Jarosław
Repich, Hlib
Wierup, Nils
Lozinska, Liudmyla
author_facet Pierzynowski, Stefan G.
Goncharova, Kateryna
Gregory, Peter C.
Weström, Björn
Podpryatov, Sergiy E.
Podpriatov, Sergii S.
Woliński, Jarosław
Repich, Hlib
Wierup, Nils
Lozinska, Liudmyla
author_sort Pierzynowski, Stefan G.
collection PubMed
description The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes – probably amylase or its peptides – on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.
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spelling pubmed-55611922017-08-21 Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model Pierzynowski, Stefan G. Goncharova, Kateryna Gregory, Peter C. Weström, Björn Podpryatov, Sergiy E. Podpriatov, Sergii S. Woliński, Jarosław Repich, Hlib Wierup, Nils Lozinska, Liudmyla Sci Rep Article The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes – probably amylase or its peptides – on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes. Nature Publishing Group UK 2017-08-17 /pmc/articles/PMC5561192/ /pubmed/28819193 http://dx.doi.org/10.1038/s41598-017-07387-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pierzynowski, Stefan G.
Goncharova, Kateryna
Gregory, Peter C.
Weström, Björn
Podpryatov, Sergiy E.
Podpriatov, Sergii S.
Woliński, Jarosław
Repich, Hlib
Wierup, Nils
Lozinska, Liudmyla
Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_full Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_fullStr Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_full_unstemmed Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_short Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_sort experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561192/
https://www.ncbi.nlm.nih.gov/pubmed/28819193
http://dx.doi.org/10.1038/s41598-017-07387-2
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