Spag6 Mutant Mice Have Defects in Development and Function of Spiral Ganglion Neurons, Apoptosis, and Higher Sensitivity to Paclitaxel

Mammalian Sperm Associated Antigen 6 (SPAG6) is the orthologue of Chlamydomonas PF16, a protein localized in the axoneme central apparatus. Recent studies showed that Spag6 has a role in brain neuronal proliferation and differentiation. The mammalian spiral ganglion neurons (SGNs) are specialzed bip...

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Detalles Bibliográficos
Autores principales: Li, Xiaofei, Xu, Lei, Sun, Gaoying, Wu, Xianmin, Bai, Xiaohui, Li, Jianfeng, Strauss, Jerome F., Zhang, Zhibing, Wang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561245/
https://www.ncbi.nlm.nih.gov/pubmed/28819108
http://dx.doi.org/10.1038/s41598-017-08739-8

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