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Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder

Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring e...

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Autores principales: Baczkowski, Blazej M., van Zutphen, Linda, Siep, Nicolette, Jacob, Gitta A., Domes, Gregor, Maier, Simon, Sprenger, Andreas, Senft, Alena, Willenborg, Bastian, Tüscher, Oliver, Arntz, Arnoud, van de Ven, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561271/
https://www.ncbi.nlm.nih.gov/pubmed/28039553
http://dx.doi.org/10.1007/s00406-016-0760-z
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author Baczkowski, Blazej M.
van Zutphen, Linda
Siep, Nicolette
Jacob, Gitta A.
Domes, Gregor
Maier, Simon
Sprenger, Andreas
Senft, Alena
Willenborg, Bastian
Tüscher, Oliver
Arntz, Arnoud
van de Ven, Vincent
author_facet Baczkowski, Blazej M.
van Zutphen, Linda
Siep, Nicolette
Jacob, Gitta A.
Domes, Gregor
Maier, Simon
Sprenger, Andreas
Senft, Alena
Willenborg, Bastian
Tüscher, Oliver
Arntz, Arnoud
van de Ven, Vincent
author_sort Baczkowski, Blazej M.
collection PubMed
description Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subsequently, we explored whether the results are common for personality disorders characterized by emotional problems, using additional data of 21 cluster-C personality disorder patients. In contrast to non-patients, BPD patients failed to show increased post-task amygdala resting-state FC with the medial, dorsolateral, ventrolateral PFC, and superior temporal gyrus, but surprisingly exhibited decreased FC with the posterior cingulate cortex and increased FC with the superior parietal lobule. In BPD patients, the emotion regulation task failed to increase resting-state amygdala FC with brain regions essential for effortful emotion regulation, which suggests: (a) altered cognitive control typically used to indirectly alleviate distress by reinterpreting the meaning of emotional stimuli; (b) impaired direct regulation of emotional responses, which might be common for personality disorders; (c) avoidance of self-related appraisals induced by social emotional stimuli. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00406-016-0760-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-55612712017-09-01 Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder Baczkowski, Blazej M. van Zutphen, Linda Siep, Nicolette Jacob, Gitta A. Domes, Gregor Maier, Simon Sprenger, Andreas Senft, Alena Willenborg, Bastian Tüscher, Oliver Arntz, Arnoud van de Ven, Vincent Eur Arch Psychiatry Clin Neurosci Original Paper Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subsequently, we explored whether the results are common for personality disorders characterized by emotional problems, using additional data of 21 cluster-C personality disorder patients. In contrast to non-patients, BPD patients failed to show increased post-task amygdala resting-state FC with the medial, dorsolateral, ventrolateral PFC, and superior temporal gyrus, but surprisingly exhibited decreased FC with the posterior cingulate cortex and increased FC with the superior parietal lobule. In BPD patients, the emotion regulation task failed to increase resting-state amygdala FC with brain regions essential for effortful emotion regulation, which suggests: (a) altered cognitive control typically used to indirectly alleviate distress by reinterpreting the meaning of emotional stimuli; (b) impaired direct regulation of emotional responses, which might be common for personality disorders; (c) avoidance of self-related appraisals induced by social emotional stimuli. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00406-016-0760-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-12-30 2017 /pmc/articles/PMC5561271/ /pubmed/28039553 http://dx.doi.org/10.1007/s00406-016-0760-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Baczkowski, Blazej M.
van Zutphen, Linda
Siep, Nicolette
Jacob, Gitta A.
Domes, Gregor
Maier, Simon
Sprenger, Andreas
Senft, Alena
Willenborg, Bastian
Tüscher, Oliver
Arntz, Arnoud
van de Ven, Vincent
Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
title Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
title_full Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
title_fullStr Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
title_full_unstemmed Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
title_short Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
title_sort deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561271/
https://www.ncbi.nlm.nih.gov/pubmed/28039553
http://dx.doi.org/10.1007/s00406-016-0760-z
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