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Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice
INTRODUCTION: Cognitive impairment is the core symptom of schizophrenia, significantly impacting the functional outcome. Improvement of cognitive function has been an important aspect of the treatment of schizophrenia. Therefore, this study is to demonstrate the effects of first‐generation antipsych...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561323/ https://www.ncbi.nlm.nih.gov/pubmed/28828223 http://dx.doi.org/10.1002/brb3.764 |
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author | Ning, Houxu Cao, Dong Wang, Haidong Kang, Bing Xie, Shiping Meng, Yujing |
author_facet | Ning, Houxu Cao, Dong Wang, Haidong Kang, Bing Xie, Shiping Meng, Yujing |
author_sort | Ning, Houxu |
collection | PubMed |
description | INTRODUCTION: Cognitive impairment is the core symptom of schizophrenia, significantly impacting the functional outcome. Improvement of cognitive function has been an important aspect of the treatment of schizophrenia. Therefore, this study is to demonstrate the effects of first‐generation antipsychotic haloperidol, second‐generation antipsychotic olanzapine and ziprasidone, and alpha‐7 nicotinic acetylcholine receptor agonist PHA‐543613 on spatial learning and memory. MATERIAL AND METHODS: C57BL/6 mice received intraperitoneal injections of haloperidol (2 mg/kg), olanzapine (2.5 mg/kg), ziprasidone (2 mg/kg), and PHA‐543613 (1 mg/kg), and cognitive dysfunctions were induced by MK‐801 (0.1 mg/kg). Morris water maze was used for investigating the effects of all agents. RESULTS: Mk‐801 significantly increased the mean escape latency to the platform and decreased the number of platform area crossings. Ziprasidone had no effect on the mean escape latency to platform and the number of platform area crossings in naïve mice, but haloperidol, olanzapine, and PHA‐543613 did not. Haloperidol and olanzapine significantly increased the mean escape latency to platform and decreased the number of platform area crossings, while ziprasidone and PHA‐543613 did not. All the agents had no effect on swimming speed. CONCLUSIONS: Ziprasidone and alpha‐7 nicotinic acetylcholine receptor agonist PHA‐543613 might be helpful in the treatment of CIAS. |
format | Online Article Text |
id | pubmed-5561323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55613232017-08-21 Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice Ning, Houxu Cao, Dong Wang, Haidong Kang, Bing Xie, Shiping Meng, Yujing Brain Behav Original Research INTRODUCTION: Cognitive impairment is the core symptom of schizophrenia, significantly impacting the functional outcome. Improvement of cognitive function has been an important aspect of the treatment of schizophrenia. Therefore, this study is to demonstrate the effects of first‐generation antipsychotic haloperidol, second‐generation antipsychotic olanzapine and ziprasidone, and alpha‐7 nicotinic acetylcholine receptor agonist PHA‐543613 on spatial learning and memory. MATERIAL AND METHODS: C57BL/6 mice received intraperitoneal injections of haloperidol (2 mg/kg), olanzapine (2.5 mg/kg), ziprasidone (2 mg/kg), and PHA‐543613 (1 mg/kg), and cognitive dysfunctions were induced by MK‐801 (0.1 mg/kg). Morris water maze was used for investigating the effects of all agents. RESULTS: Mk‐801 significantly increased the mean escape latency to the platform and decreased the number of platform area crossings. Ziprasidone had no effect on the mean escape latency to platform and the number of platform area crossings in naïve mice, but haloperidol, olanzapine, and PHA‐543613 did not. Haloperidol and olanzapine significantly increased the mean escape latency to platform and decreased the number of platform area crossings, while ziprasidone and PHA‐543613 did not. All the agents had no effect on swimming speed. CONCLUSIONS: Ziprasidone and alpha‐7 nicotinic acetylcholine receptor agonist PHA‐543613 might be helpful in the treatment of CIAS. John Wiley and Sons Inc. 2017-07-11 /pmc/articles/PMC5561323/ /pubmed/28828223 http://dx.doi.org/10.1002/brb3.764 Text en © 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Ning, Houxu Cao, Dong Wang, Haidong Kang, Bing Xie, Shiping Meng, Yujing Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice |
title | Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice |
title_full | Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice |
title_fullStr | Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice |
title_full_unstemmed | Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice |
title_short | Effects of haloperidol, olanzapine, ziprasidone, and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice |
title_sort | effects of haloperidol, olanzapine, ziprasidone, and pha‐543613 on spatial learning and memory in the morris water maze test in naïve and mk‐801‐treated mice |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561323/ https://www.ncbi.nlm.nih.gov/pubmed/28828223 http://dx.doi.org/10.1002/brb3.764 |
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