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A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)

BACKGROUND: Memantine is an N-methyl-D-Aspartate (NMDA) antagonist. By transferring acute postoperative pain, the NMDA channels may lead to active excess and neuropathic pain. Objectives: This study attempted to investigate the effect of preoperative use of single oral dose of memantine in controlli...

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Autores principales: Rahimzadeh, Poupak, Imani, Farnad, Nikoubakht, Nasim, Koleini, Zahra, Faiz, Seyed Hamid Reza, Sayarifard, Azadeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561447/
https://www.ncbi.nlm.nih.gov/pubmed/28856113
http://dx.doi.org/10.5812/aapm.45297
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author Rahimzadeh, Poupak
Imani, Farnad
Nikoubakht, Nasim
Koleini, Zahra
Faiz, Seyed Hamid Reza
Sayarifard, Azadeh
author_facet Rahimzadeh, Poupak
Imani, Farnad
Nikoubakht, Nasim
Koleini, Zahra
Faiz, Seyed Hamid Reza
Sayarifard, Azadeh
author_sort Rahimzadeh, Poupak
collection PubMed
description BACKGROUND: Memantine is an N-methyl-D-Aspartate (NMDA) antagonist. By transferring acute postoperative pain, the NMDA channels may lead to active excess and neuropathic pain. Objectives: This study attempted to investigate the effect of preoperative use of single oral dose of memantine in controlling Dacryocystorhinostomy (DCR) postoperative pain. METHODS: A double-blind clinical trial was conducted on 60 patients undergoing DCR. On arrival at the operating room, the memantine group received 20 mg of oral memantine and the control group received placebo. The severities of pain by visual analogue scale (VAS) and sedation by Ramsy Scale were measured immediately 1, 2, and 6 hours after the operation. The drug’s side effects were recorded. RESULTS: The pain scores of patients in the recovery in 1, 2, and 6 hours after operation were significantly lower in the memantine group than the placebo group (P < 0.001). The sedation score, 1 hour after the operation, was significantly greater in the memantine group than the placebo (P < 0.001). The sedation scores did not have any statistically significant difference in recovery and 2 hours after surgery between the two groups. Moreover, the sedation scores in 6 hours after the surgery were identical in the two groups. CONCLUSIONS: The oral single-dose 20 mg of memantine administered before DCR can reduce postoperative pain compared with placebo.
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spelling pubmed-55614472017-08-30 A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR) Rahimzadeh, Poupak Imani, Farnad Nikoubakht, Nasim Koleini, Zahra Faiz, Seyed Hamid Reza Sayarifard, Azadeh Anesth Pain Med Research Article BACKGROUND: Memantine is an N-methyl-D-Aspartate (NMDA) antagonist. By transferring acute postoperative pain, the NMDA channels may lead to active excess and neuropathic pain. Objectives: This study attempted to investigate the effect of preoperative use of single oral dose of memantine in controlling Dacryocystorhinostomy (DCR) postoperative pain. METHODS: A double-blind clinical trial was conducted on 60 patients undergoing DCR. On arrival at the operating room, the memantine group received 20 mg of oral memantine and the control group received placebo. The severities of pain by visual analogue scale (VAS) and sedation by Ramsy Scale were measured immediately 1, 2, and 6 hours after the operation. The drug’s side effects were recorded. RESULTS: The pain scores of patients in the recovery in 1, 2, and 6 hours after operation were significantly lower in the memantine group than the placebo group (P < 0.001). The sedation score, 1 hour after the operation, was significantly greater in the memantine group than the placebo (P < 0.001). The sedation scores did not have any statistically significant difference in recovery and 2 hours after surgery between the two groups. Moreover, the sedation scores in 6 hours after the surgery were identical in the two groups. CONCLUSIONS: The oral single-dose 20 mg of memantine administered before DCR can reduce postoperative pain compared with placebo. Kowsar 2017-04-26 /pmc/articles/PMC5561447/ /pubmed/28856113 http://dx.doi.org/10.5812/aapm.45297 Text en Copyright © 2017, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Rahimzadeh, Poupak
Imani, Farnad
Nikoubakht, Nasim
Koleini, Zahra
Faiz, Seyed Hamid Reza
Sayarifard, Azadeh
A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)
title A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)
title_full A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)
title_fullStr A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)
title_full_unstemmed A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)
title_short A Comparative Study on the Efficacy of Oral Memantine and Placebo for Acute Postoperative Pain in Patients Undergoing Dacryocystorhinostomy (DCR)
title_sort comparative study on the efficacy of oral memantine and placebo for acute postoperative pain in patients undergoing dacryocystorhinostomy (dcr)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561447/
https://www.ncbi.nlm.nih.gov/pubmed/28856113
http://dx.doi.org/10.5812/aapm.45297
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