Transforming activity and therapeutic targeting of C-terminal Binding Protein 2 in Apc mutated neoplasia

Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP) occurs in many human solid tumors and is associated with poor prognosis. CtBP modulates oncogenic gene expression programs and is an emerging drug target, but its oncogenic role is unclear. Consistent with...

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Detalles Bibliográficos
Autores principales: Sumner, Evan T., Chawla, Ayesha T., Cororaton, Agnes D., Koblinski, Jennifer, Kovi, Ramesh C., Love, Ian M., Szomju, Barbara B., Korwar, Sudha, Ellis, Keith C., Grossman, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561459/
https://www.ncbi.nlm.nih.gov/pubmed/28414304
http://dx.doi.org/10.1038/onc.2017.106

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