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Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

BACKGROUND: Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differentiation leading to tumorigenesis. Although surgical intervention can remove...

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Detalles Bibliográficos
Autores principales:	Brown, Robert E., Naqvi, Syed, McGuire, Mary F., Buryanek, Jamie, Karni, Ron J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561614/ https://www.ncbi.nlm.nih.gov/pubmed/28818106 http://dx.doi.org/10.1186/s40463-017-0230-2

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