Cargando…
Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial
BACKGROUND: Cutaneous warts are treated primarily with destructive methods such as cryotherapy or electrocautery. These modalities of treatment are time-consuming and may be associated with scarring in multiple warts. Immunotherapy is emerging as a new modality of treatment which acts on enhancing c...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561717/ https://www.ncbi.nlm.nih.gov/pubmed/28852295 http://dx.doi.org/10.4103/JCAS.JCAS_82_16 |
_version_ | 1783257883366916096 |
---|---|
author | Kavya, Manjunath Shashikumar, Basavapura Madegowda Harish, Muddanahalli Rajegowda Shweta, Bhadbhade P |
author_facet | Kavya, Manjunath Shashikumar, Basavapura Madegowda Harish, Muddanahalli Rajegowda Shweta, Bhadbhade P |
author_sort | Kavya, Manjunath |
collection | PubMed |
description | BACKGROUND: Cutaneous warts are treated primarily with destructive methods such as cryotherapy or electrocautery. These modalities of treatment are time-consuming and may be associated with scarring in multiple warts. Immunotherapy is emerging as a new modality of treatment which acts on enhancing cell-mediated immunity against human papillomavirus for clearance of both treated and distant warts. AIMS: This study aims to evaluate the safety and efficacy of intralesional Vitamin D3 for the treatment of cutaneous warts. MATERIALS AND METHODS: Patients with multiple warts were selected for immunotherapy. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of warts after injecting with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated 2 weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of 2 warts were treated per session and patients were followed up for 6 months after the last injection. RESULTS: Forty-two patients with multiple warts were recruited for the study who completed the 6-month follow-up period and were available for analysis. Of these, 23 had palmoplantar warts, 18 had verruca vulgaris and 1 patient had filiform wart. In total, 33 of 42 patients (78.57%) showed complete response, 6 patients (14.28%) showed moderate response and three patients (7.14%) showed mild response. Recurrence was observed in one patient with the palmoplantar wart. No serious adverse effects were reported. LIMITATIONS: Lack of control group was the main drawback in our study. CONCLUSION: Intralesional Vitamin D3 is safe and effective for treatment of multiple cutaneous warts. |
format | Online Article Text |
id | pubmed-5561717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55617172017-08-29 Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial Kavya, Manjunath Shashikumar, Basavapura Madegowda Harish, Muddanahalli Rajegowda Shweta, Bhadbhade P J Cutan Aesthet Surg Original Article BACKGROUND: Cutaneous warts are treated primarily with destructive methods such as cryotherapy or electrocautery. These modalities of treatment are time-consuming and may be associated with scarring in multiple warts. Immunotherapy is emerging as a new modality of treatment which acts on enhancing cell-mediated immunity against human papillomavirus for clearance of both treated and distant warts. AIMS: This study aims to evaluate the safety and efficacy of intralesional Vitamin D3 for the treatment of cutaneous warts. MATERIALS AND METHODS: Patients with multiple warts were selected for immunotherapy. Vitamin D3 (0.2 ml, 15 mg/ml) was injected to the base of warts after injecting with lignocaine (0.2 ml, 20 mg/ml). The injections were repeated 2 weeks apart for a maximum of 4 sessions or until complete clearance, whichever was earlier. A maximum of 2 warts were treated per session and patients were followed up for 6 months after the last injection. RESULTS: Forty-two patients with multiple warts were recruited for the study who completed the 6-month follow-up period and were available for analysis. Of these, 23 had palmoplantar warts, 18 had verruca vulgaris and 1 patient had filiform wart. In total, 33 of 42 patients (78.57%) showed complete response, 6 patients (14.28%) showed moderate response and three patients (7.14%) showed mild response. Recurrence was observed in one patient with the palmoplantar wart. No serious adverse effects were reported. LIMITATIONS: Lack of control group was the main drawback in our study. CONCLUSION: Intralesional Vitamin D3 is safe and effective for treatment of multiple cutaneous warts. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5561717/ /pubmed/28852295 http://dx.doi.org/10.4103/JCAS.JCAS_82_16 Text en Copyright: © 2017 Journal of Cutaneous and Aesthetic Surgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kavya, Manjunath Shashikumar, Basavapura Madegowda Harish, Muddanahalli Rajegowda Shweta, Bhadbhade P Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial |
title | Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial |
title_full | Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial |
title_fullStr | Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial |
title_full_unstemmed | Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial |
title_short | Safety and Efficacy of Intralesional Vitamin D3 in Cutaneous Warts: An Open Uncontrolled Trial |
title_sort | safety and efficacy of intralesional vitamin d3 in cutaneous warts: an open uncontrolled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561717/ https://www.ncbi.nlm.nih.gov/pubmed/28852295 http://dx.doi.org/10.4103/JCAS.JCAS_82_16 |
work_keys_str_mv | AT kavyamanjunath safetyandefficacyofintralesionalvitamind3incutaneouswartsanopenuncontrolledtrial AT shashikumarbasavapuramadegowda safetyandefficacyofintralesionalvitamind3incutaneouswartsanopenuncontrolledtrial AT harishmuddanahallirajegowda safetyandefficacyofintralesionalvitamind3incutaneouswartsanopenuncontrolledtrial AT shwetabhadbhadep safetyandefficacyofintralesionalvitamind3incutaneouswartsanopenuncontrolledtrial |