Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson's disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway

In Parkinson's disease (PD), microglial activation-mediated neuroinflammation is associated with dopaminergic neurons degeneration in the substantia nigra pars compacta. Previous studies that have investigated this neurodegenerative disease have reported that the Sonic hedgehog (SHH) signaling...

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Detalles Bibliográficos
Autores principales: Shao, Shuai, Wang, Guang-Liang, Raymond, Cespuglio, Deng, Xue-Hua, Zhu, Xiao-Lan, Wang, Di, Hong, Le-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562000/
https://www.ncbi.nlm.nih.gov/pubmed/28627590
http://dx.doi.org/10.3892/mmr.2017.6751

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