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Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination
Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β-catenin signaling. However, recent s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562062/ https://www.ncbi.nlm.nih.gov/pubmed/28656232 http://dx.doi.org/10.3892/mmr.2017.6843 |
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author | Weng, Chao Ding, Man Fan, Shanghua Cao, Qian Lu, Zuneng |
author_facet | Weng, Chao Ding, Man Fan, Shanghua Cao, Qian Lu, Zuneng |
author_sort | Weng, Chao |
collection | PubMed |
description | Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β-catenin signaling. However, recent studies indicated that TCF7L2 activity is required during oligodendrocyte differentiation and remyelination. In order to clarify this, in situ hybridization, immunofluorescence and western blot analysis using in vivo TCF7L2 conditional knockout mice, were performed and it was found that TCF7L2 promotes oligodendrocyte differentiation during myelin formation and remyelination. Furthermore, it was established that TCF7L2 does not affect oligodendrocyte precursor cells during remyelination. These data are of important clinical significance to develop novel therapeutic targets to overcome multiple sclerosis and other demyelinating diseases. |
format | Online Article Text |
id | pubmed-5562062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-55620622017-10-23 Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination Weng, Chao Ding, Man Fan, Shanghua Cao, Qian Lu, Zuneng Mol Med Rep Articles Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β-catenin signaling. However, recent studies indicated that TCF7L2 activity is required during oligodendrocyte differentiation and remyelination. In order to clarify this, in situ hybridization, immunofluorescence and western blot analysis using in vivo TCF7L2 conditional knockout mice, were performed and it was found that TCF7L2 promotes oligodendrocyte differentiation during myelin formation and remyelination. Furthermore, it was established that TCF7L2 does not affect oligodendrocyte precursor cells during remyelination. These data are of important clinical significance to develop novel therapeutic targets to overcome multiple sclerosis and other demyelinating diseases. D.A. Spandidos 2017-08 2017-06-22 /pmc/articles/PMC5562062/ /pubmed/28656232 http://dx.doi.org/10.3892/mmr.2017.6843 Text en Copyright: © Weng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Weng, Chao Ding, Man Fan, Shanghua Cao, Qian Lu, Zuneng Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
title | Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
title_full | Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
title_fullStr | Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
title_full_unstemmed | Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
title_short | Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
title_sort | transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562062/ https://www.ncbi.nlm.nih.gov/pubmed/28656232 http://dx.doi.org/10.3892/mmr.2017.6843 |
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