Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and Connexin43 downregulation in H9c2 cells

Background: Increased cardiomyocyte apoptosis under high glucose condition contributes to diabetic cardiomyopathy. Degradation of cardiac Connexin43 (Cx43) has been associated with cardiac dysfunction in diabetic heart. Clinical and experimental studies suggested that metformin (Met) exhibits cardio...

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Detalles Bibliográficos
Autores principales: Wang, Guang-Yu, Bi, Ya-Guang, Liu, Xiang-Dong, Zhao, Yu, Han, Jun-Feng, Wei, Meng, Zhang, Qing-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562122/
https://www.ncbi.nlm.nih.gov/pubmed/28824303
http://dx.doi.org/10.7150/ijms.19800

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