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Phosphatidlyinositol-3-kinase C2 beta (PI3KC2β) is a potential new target to treat IgE mediated disease

Cross linking of the IgE receptor (FcεRI) on mast cells plays a critical role in IgE-dependent allergy including allergic rhinitis, asthma, anaphylaxis, and delayed type hypersensitivity reactions. The Ca(2+) activated K(+) channel, KCa3.1, plays a critical role in IgE-stimulated Ca(2+) entry and de...

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Detalles Bibliográficos
Autores principales:	Srivastava, Shekhar, Li, Zhai, Skolnik, Edward Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562315/ https://www.ncbi.nlm.nih.gov/pubmed/28820911 http://dx.doi.org/10.1371/journal.pone.0183474

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