A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute to this regulatory orchestra. We identified a rode...

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Detalles Bibliográficos
Autores principales: Li, Meng Amy, Amaral, Paulo P, Cheung, Priscilla, Bergmann, Jan H, Kinoshita, Masaki, Kalkan, Tüzer, Ralser, Meryem, Robson, Sam, von Meyenn, Ferdinand, Paramor, Maike, Yang, Fengtang, Chen, Caifu, Nichols, Jennifer, Spector, David L, Kouzarides, Tony, He, Lin, Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562443/
https://www.ncbi.nlm.nih.gov/pubmed/28820723
http://dx.doi.org/10.7554/eLife.23468

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