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Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats

Environmental pollution and exposure to environmental pollutants are still some of the major global health issues. Pesticides have been linked to a wide range of health hazards. The toxicity of pesticides depends on several factors such as its chemical properties, doses, exposure period, exposure me...

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Autores principales: Al-Attar, Atef M., Elnaggar, Moustafa H.R., Almalki, Essam A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562457/
https://www.ncbi.nlm.nih.gov/pubmed/28855808
http://dx.doi.org/10.1016/j.sjbs.2016.10.013
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author Al-Attar, Atef M.
Elnaggar, Moustafa H.R.
Almalki, Essam A.
author_facet Al-Attar, Atef M.
Elnaggar, Moustafa H.R.
Almalki, Essam A.
author_sort Al-Attar, Atef M.
collection PubMed
description Environmental pollution and exposure to environmental pollutants are still some of the major global health issues. Pesticides have been linked to a wide range of health hazards. The toxicity of pesticides depends on several factors such as its chemical properties, doses, exposure period, exposure methods, gender, genetics, age, nutritional status and physiological case of exposed individuals. Medicinal plants, natural products and nutrition continue to play a central role in the healthcare system of large proportions of the world’s population. Alternative medicine plays an important role in health services around the world. The aim of this study was to investigate the effect of olive, sesame and black seed oils on hepatorenal toxicity induced by diazinon (DZN) in male rats. The experimental animals were divided into nine groups. The first group served as control. The second group was exposed to DZN. The third group was treated with olive oil and DZN. Rats of the fourth group were subjected to sesame oil and DZN. Rats of the fifth group were exposed to black seed oil and DZN. The sixth, seventh and eighth groups were supplemented with olive, sesame and black seed oils respectively. Rats of the ninth group were treated with corn oil. Levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, creatinine, blood urea nitrogen and malondialdehyde were significantly increased in rats exposed to DZN. Moreover, levels of serum glutathione and superoxide dismutase were significantly decreased. Several histopathological changes were observed in the structures of liver and kidney due to DZN exposure. This study showed that these oils attenuated the physiological disturbances and histopathological alterations induced by DZN intoxication. Moreover, the antioxidant properties of these oils support the bioactive roles of its protective effects on DZN toxicity. This study therefore suggests that these oils could be used as preventive factors against the toxicity of DZN due to its antioxidant properties.
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spelling pubmed-55624572017-08-30 Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats Al-Attar, Atef M. Elnaggar, Moustafa H.R. Almalki, Essam A. Saudi J Biol Sci Original Article Environmental pollution and exposure to environmental pollutants are still some of the major global health issues. Pesticides have been linked to a wide range of health hazards. The toxicity of pesticides depends on several factors such as its chemical properties, doses, exposure period, exposure methods, gender, genetics, age, nutritional status and physiological case of exposed individuals. Medicinal plants, natural products and nutrition continue to play a central role in the healthcare system of large proportions of the world’s population. Alternative medicine plays an important role in health services around the world. The aim of this study was to investigate the effect of olive, sesame and black seed oils on hepatorenal toxicity induced by diazinon (DZN) in male rats. The experimental animals were divided into nine groups. The first group served as control. The second group was exposed to DZN. The third group was treated with olive oil and DZN. Rats of the fourth group were subjected to sesame oil and DZN. Rats of the fifth group were exposed to black seed oil and DZN. The sixth, seventh and eighth groups were supplemented with olive, sesame and black seed oils respectively. Rats of the ninth group were treated with corn oil. Levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, creatinine, blood urea nitrogen and malondialdehyde were significantly increased in rats exposed to DZN. Moreover, levels of serum glutathione and superoxide dismutase were significantly decreased. Several histopathological changes were observed in the structures of liver and kidney due to DZN exposure. This study showed that these oils attenuated the physiological disturbances and histopathological alterations induced by DZN intoxication. Moreover, the antioxidant properties of these oils support the bioactive roles of its protective effects on DZN toxicity. This study therefore suggests that these oils could be used as preventive factors against the toxicity of DZN due to its antioxidant properties. Elsevier 2017-09 2016-10-20 /pmc/articles/PMC5562457/ /pubmed/28855808 http://dx.doi.org/10.1016/j.sjbs.2016.10.013 Text en © 2016 Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Al-Attar, Atef M.
Elnaggar, Moustafa H.R.
Almalki, Essam A.
Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
title Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
title_full Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
title_fullStr Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
title_full_unstemmed Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
title_short Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
title_sort protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562457/
https://www.ncbi.nlm.nih.gov/pubmed/28855808
http://dx.doi.org/10.1016/j.sjbs.2016.10.013
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