Paying the Toll in Nuclear Reprogramming

The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by caus...

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Detalles Bibliográficos
Autores principales: Liu, Chun, Himmati, Farhan, Sayed, Nazish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562677/
https://www.ncbi.nlm.nih.gov/pubmed/28861413
http://dx.doi.org/10.3389/fcell.2017.00070
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author Liu, Chun
Himmati, Farhan
Sayed, Nazish
author_facet Liu, Chun
Himmati, Farhan
Sayed, Nazish
author_sort Liu, Chun
collection PubMed
description The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by causing global changes in the expression and activity of epigenetic modifiers. Here we discuss, in a comprehensive manner, the recent studies on the role of innate immunity in nuclear reprogramming and transdifferentiation, the underlying mechanisms, and its role in regenerative medicine.
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spelling pubmed-55626772017-08-31 Paying the Toll in Nuclear Reprogramming Liu, Chun Himmati, Farhan Sayed, Nazish Front Cell Dev Biol Cell and Developmental Biology The ability to reverse lineage-committed cells toward pluripotent stem cells or to another cell type is one of the ultimate goals in regenerative medicine. We recently discovered that activation of innate immunity, through Toll-like receptor 3, is required during this conversion of cell fate by causing global changes in the expression and activity of epigenetic modifiers. Here we discuss, in a comprehensive manner, the recent studies on the role of innate immunity in nuclear reprogramming and transdifferentiation, the underlying mechanisms, and its role in regenerative medicine. Frontiers Media S.A. 2017-08-17 /pmc/articles/PMC5562677/ /pubmed/28861413 http://dx.doi.org/10.3389/fcell.2017.00070 Text en Copyright © 2017 Liu, Himmati and Sayed. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Liu, Chun
Himmati, Farhan
Sayed, Nazish
Paying the Toll in Nuclear Reprogramming
title Paying the Toll in Nuclear Reprogramming
title_full Paying the Toll in Nuclear Reprogramming
title_fullStr Paying the Toll in Nuclear Reprogramming
title_full_unstemmed Paying the Toll in Nuclear Reprogramming
title_short Paying the Toll in Nuclear Reprogramming
title_sort paying the toll in nuclear reprogramming
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562677/
https://www.ncbi.nlm.nih.gov/pubmed/28861413
http://dx.doi.org/10.3389/fcell.2017.00070
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