Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice

Earlier we demonstrated that the adenylyl cyclase (AC) encoded by the MSMEG_4279 gene plays a key role in the resuscitation and growth of dormant Mycobacterium smegmatis and that overexpression of this gene leads to an increase in intracellular cAMP concentration and prevents the transition of M. sm...

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Detalles Bibliográficos
Autores principales: Shleeva, Margarita O., Kondratieva, Tatyana K., Demina, Galina R., Rubakova, Elvira I., Goncharenko, Anna V., Apt, Alexander S., Kaprelyants, Arseny S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562752/
https://www.ncbi.nlm.nih.gov/pubmed/28861399
http://dx.doi.org/10.3389/fcimb.2017.00370

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