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Rap1 and Cdc13 have complementary roles in preventing exonucleolytic degradation of telomere 5′ ends
Telomere DNA ends with a single-stranded 3′ overhang. Long 3′ overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5′ end hyper-resection, y...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562816/ https://www.ncbi.nlm.nih.gov/pubmed/28821750 http://dx.doi.org/10.1038/s41598-017-08663-x |