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Selective targeting p53(WT) lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA

TP53 plays essential roles in tumor initiation and progression, and is frequently mutated in cancer. However, pharmacological stabilization and reactivation of p53 have not been actively explored for targeted cancer therapies. Herein, we identify a novel Cyclophilin A (CypA) small molecule inhibitor...

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Detalles Bibliográficos
Autores principales:	Lu, W, Cheng, F, Yan, W, Li, X, Yao, X, Song, W, Liu, M, Shen, X, Jiang, H, Chen, J, Li, J, Huang, J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562848/ https://www.ncbi.nlm.nih.gov/pubmed/28394340 http://dx.doi.org/10.1038/onc.2017.41

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