NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We found that Nos2 (−/−) mice incapable of NO-prod...

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Detalles Bibliográficos
Autores principales: Gengenbacher, Martin, Duque-Correa, Maria A., Kaiser, Peggy, Schuerer, Stefanie, Lazar, Doris, Zedler, Ulrike, Reece, Stephen T., Nayyar, Amit, Cole, Stewart T., Makarov, Vadim, Barry III, Clifton E., Dartois, Véronique, Kaufmann, Stefan H. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562869/
https://www.ncbi.nlm.nih.gov/pubmed/28821804
http://dx.doi.org/10.1038/s41598-017-09177-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562869/
https://www.ncbi.nlm.nih.gov/pubmed/28821804
http://dx.doi.org/10.1038/s41598-017-09177-2

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