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Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 adult subj...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562916/ https://www.ncbi.nlm.nih.gov/pubmed/28821853 http://dx.doi.org/10.1038/s41598-017-09455-z |
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author | Dong, Huimin Xu, Yang Zhang, Xiuzhi Tian, Simiao |
author_facet | Dong, Huimin Xu, Yang Zhang, Xiuzhi Tian, Simiao |
author_sort | Dong, Huimin |
collection | PubMed |
description | Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 adult subjects from the China Health and Nutrition Survey 2009 were retained. Subjects were categorized into four obesity phenotypes based on a cross-classification of BMI and metabolic health status by two representative criteria. VAI was the best predictors for hyperuricemia irrespective of obesity phenotypes, with area under curve (AUC) ranging 0.665–0.719. The odd ratio (OR) for hyperuricemia in the highest quartile of the VAI were 6.93 (95% CI 5.79–8.29) after adjusting for age and gender. Following further adjustments for metabolic obesity phenotypes and lifestyle confounders, the ORs were 4.88 (3.92–6.09) and 5.65 (4.68–6.82) according to these two criteria, respectively. A similar significant pattern was still found even after adjustment for blood pressure and other cardiovascular risks. Within each metabolic obesity phenotype, the significant association between VAI and hyperuricemia was consistently evident. In conclusion, the association of the VAI with hyperuricemia was significant, especially this association was independent of metabolic health and obesity phenotypes in the Chinese population. |
format | Online Article Text |
id | pubmed-5562916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55629162017-08-21 Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes Dong, Huimin Xu, Yang Zhang, Xiuzhi Tian, Simiao Sci Rep Article Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 adult subjects from the China Health and Nutrition Survey 2009 were retained. Subjects were categorized into four obesity phenotypes based on a cross-classification of BMI and metabolic health status by two representative criteria. VAI was the best predictors for hyperuricemia irrespective of obesity phenotypes, with area under curve (AUC) ranging 0.665–0.719. The odd ratio (OR) for hyperuricemia in the highest quartile of the VAI were 6.93 (95% CI 5.79–8.29) after adjusting for age and gender. Following further adjustments for metabolic obesity phenotypes and lifestyle confounders, the ORs were 4.88 (3.92–6.09) and 5.65 (4.68–6.82) according to these two criteria, respectively. A similar significant pattern was still found even after adjustment for blood pressure and other cardiovascular risks. Within each metabolic obesity phenotype, the significant association between VAI and hyperuricemia was consistently evident. In conclusion, the association of the VAI with hyperuricemia was significant, especially this association was independent of metabolic health and obesity phenotypes in the Chinese population. Nature Publishing Group UK 2017-08-18 /pmc/articles/PMC5562916/ /pubmed/28821853 http://dx.doi.org/10.1038/s41598-017-09455-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Dong, Huimin Xu, Yang Zhang, Xiuzhi Tian, Simiao Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
title | Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
title_full | Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
title_fullStr | Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
title_full_unstemmed | Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
title_short | Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
title_sort | visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562916/ https://www.ncbi.nlm.nih.gov/pubmed/28821853 http://dx.doi.org/10.1038/s41598-017-09455-z |
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