Cargando…

The CREST-E study of creatine for Huntington disease: A randomized controlled trial

OBJECTIVE: To investigate whether creatine administration could slow progressive functional decline in adults with early symptoms of Huntington disease. METHODS: We conducted a multicenter, randomized, double-blind, placebo-controlled study of up to 40 g daily of creatine monohydrate in participants...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hersch, Steven M., Schifitto, Giovanni, Oakes, David, Bredlau, Amy-Lee, Meyers, Catherine M., Nahin, Richard, Rosas, Herminia Diana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562960/ https://www.ncbi.nlm.nih.gov/pubmed/28701493 http://dx.doi.org/10.1212/WNL.0000000000004209

Ejemplares similares

Impaired Cerebrovascular Reactivity in Huntington’s Disease
por: Chan, Suk Tak, et al.
Publicado: (2021)

Association of Dilated Perivascular Spaces and Disease Severity in Patients With Huntington Disease
por: Chan, Suk Tak, et al.
Publicado: (2021)

A systems-level “misunderstanding”: the plasma metabolome in Huntington’s disease
por: Rosas, Herminia D, et al.
Publicado: (2015)

To Sleep to Dream … No More? The Quest for Restorative Sleep in Huntington’s Disease, a Clinician’s Perspective
por: Rosas, Herminia Diana
Publicado: (2023)

Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington’s Disease
por: Narayanan, K. Lakshmi, et al.
Publicado: (2015)

Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease
por: Moscovitch-Lopatin, Miriam, et al.
Publicado: (2010)

Creatine supplementation improves neural progenitor cell survival in Huntington's disease
por: Andres, Robert H, et al.
Publicado: (2016)

Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials
por: Langbehn, Douglas R., et al.
Publicado: (2020)

Association between Hypothyroidism Onset and Alzheimer Disease Onset in Adults with Down Syndrome
por: Lai, Florence, et al.
Publicado: (2021)

Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease
por: Rosas, H.D., et al.
Publicado: (2018)

Association between Inflammatory Conditions and Alzheimer’s Disease Age of Onset in Down Syndrome
por: Lai, Florence, et al.
Publicado: (2021)

Utility of the Huntington's Disease Prognostic Index Score for a Perimanifest Clinical Trial
por: Langbehn, Douglas R., et al.
Publicado: (2022)

A buffered form of creatine does not promote greater changes in muscle creatine content, body composition, or training adaptations than creatine monohydrate
por: Jagim, Andrew R, et al.
Publicado: (2012)

Mechanisms of Copper Ion Mediated Huntington's Disease Progression
por: Fox, Jonathan H., et al.
Publicado: (2007)

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine
por: Chen, Jianfang, et al.
Publicado: (2013)

The creatine kinase system and pleiotropic effects of creatine
por: Wallimann, Theo, et al.
Publicado: (2011)

The Vasopressin 1a Receptor Antagonist SRX246 Reduces Aggressive Behavior in Huntington’s Disease
por: Maibach, Hilda T., et al.
Publicado: (2022)

Creatine in Health and Disease
por: Kreider, Richard B., et al.
Publicado: (2021)

Correction: Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine
por: Chen, Jianfang, et al.
Publicado: (2013)

The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males
por: Andre, Tom, et al.
Publicado: (2015)

Searching for a better formulation to enhance muscle bioenergetics: A randomized controlled trial of creatine nitrate plus creatinine vs. creatine nitrate vs. creatine monohydrate in healthy men
por: Ostojic, Sergej M., et al.
Publicado: (2019)

Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials
por: Akuffo, Kwadwo Owusu, et al.
Publicado: (2014)

Creatine and Creatinine
por: Myers, Victor C.
Publicado: (1932)

Creatine for the Treatment of Depression
por: Kious, Brent M., et al.
Publicado: (2019)

Extremely elevated creatine kinase associated with rhabdomyolysis-induced acute kidney injury in a patient with Huntington’s disease: a case report
por: Kozik, Isabelle, et al.
Publicado: (2023)

LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington’s Disease
por: Chopra, Vanita, et al.
Publicado: (2016)

Creatine uptake in mouse hearts with genetically altered creatine levels
por: Hove, Michiel ten, et al.
Publicado: (2008)

Comparison of new forms of creatine in raising plasma creatine levels
por: Jäger, Ralf, et al.
Publicado: (2007)

The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes, and Focal Creatine Deposits
por: Bürklen, Tanja S., et al.
Publicado: (2006)

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter
por: Adriano, E., et al.
Publicado: (2017)

The Role of Creatine in the Development and Activation of Immune Responses
por: Bredahl, Eric C., et al.
Publicado: (2021)

The application of eDNA for monitoring of the Great Crested Newt in the UK
por: Rees, Helen C, et al.
Publicado: (2014)

Phenotype–genotype discrepancies in the prospective Huntington at‐risk observational study
por: Shoulson, Ira, et al.
Publicado: (2019)

Chronic Dialysis Patients Are Depleted of Creatine: Review and Rationale for Intradialytic Creatine Supplementation
por: van der Veen, Yvonne, et al.
Publicado: (2021)

The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?
por: Clarke, Holly, et al.
Publicado: (2020)

Creatine Supplementation in Children and Adolescents
por: Jagim, Andrew R., et al.
Publicado: (2021)

Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models
por: Kim, Dae Won, et al.
Publicado: (2010)

Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation
por: Santacruz, Lucia, et al.
Publicado: (2017)

Creatine Supplementation and Brain Health
por: Roschel, Hamilton, et al.
Publicado: (2021)

Augmentation of Creatine in the Heart
por: Zervou, Sevasti, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_484rcu8v8emvp8rqnqp0e7gv3u