ADAM23 promotes neuronal differentiation of human neural progenitor cells

BACKGROUND: ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation. RESULTS: In this study, we showed that ADAM23 contributes to cell survival and is involved in neuronal differentiation during the differentiation of human neural progenitor...

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Detalles Bibliográficos
Autores principales: Markus-Koch, Annett, Schmitt, Oliver, Seemann, Susanne, Lukas, Jan, Koczan, Dirk, Ernst, Mathias, Fuellen, Georg, Wree, Andreas, Rolfs, Arndt, Luo, Jiankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562998/
https://www.ncbi.nlm.nih.gov/pubmed/28828010
http://dx.doi.org/10.1186/s11658-017-0045-1
Descripción
Sumario:BACKGROUND: ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation. RESULTS: In this study, we showed that ADAM23 contributes to cell survival and is involved in neuronal differentiation during the differentiation of human neural progenitor cells (hNPCs). Upregulation of ADAM23 in hNPCs was found to increase the number of neurons and the length of neurite, while its downregulation decreases them and triggers cell apoptosis. RNA microarray analysis revealed mechanistic insights into genes and pathways that may become involved in multiple cellular processes upon up- or downregulation of ADAM23. CONCLUSIONS: Our results suggest that ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during hNPC differentiation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s11658-017-0045-1) contains supplementary material, which is available to authorized users.

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