The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

In late mitosis and G(1), origins of DNA replication must be “licensed” for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2–7. A “licensing checkpoint” delays cells in G(1) until sufficient origins have been licensed, but this checkpo...

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Detalles Bibliográficos
Autores principales: Gardner, Nicola J., Gillespie, Peter J., Carrington, Jamie T., Shanks, Emma J., McElroy, Stuart P., Haagensen, Emma J., Frearson, Julie A., Woodland, Andrew, Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563080/
https://www.ncbi.nlm.nih.gov/pubmed/28781123
http://dx.doi.org/10.1016/j.chembiol.2017.06.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563080/
https://www.ncbi.nlm.nih.gov/pubmed/28781123
http://dx.doi.org/10.1016/j.chembiol.2017.06.019

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