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Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies

BACKGROUND: The human 8-oxoguanine DNA glycosylase (hOGG1) gene may be linked with cancer susceptibility. The aim of this study was to quantitatively summarize any association between the hOGG1 Ser326Cys polymorphism and breast cancer (BC) risk. MATERIALS AND METHODS: A comprehensive search of the P...

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Autores principales: Kamali, Mahdieh, Kargar, Saeed, Heiranizadeh, Naeimeh, Zare, Mohammad, Kargar, Shadi, Shehneh, Masoud Zare, Neamatzadeh, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563108/
https://www.ncbi.nlm.nih.gov/pubmed/28240527
http://dx.doi.org/10.22034/APJCP.2017.18.1.245
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author Kamali, Mahdieh
Kargar, Saeed
Heiranizadeh, Naeimeh
Zare, Mohammad
Kargar, Shadi
Shehneh, Masoud Zare
Neamatzadeh, Hossein
author_facet Kamali, Mahdieh
Kargar, Saeed
Heiranizadeh, Naeimeh
Zare, Mohammad
Kargar, Shadi
Shehneh, Masoud Zare
Neamatzadeh, Hossein
author_sort Kamali, Mahdieh
collection PubMed
description BACKGROUND: The human 8-oxoguanine DNA glycosylase (hOGG1) gene may be linked with cancer susceptibility. The aim of this study was to quantitatively summarize any association between the hOGG1 Ser326Cys polymorphism and breast cancer (BC) risk. MATERIALS AND METHODS: A comprehensive search of the PubMed, Embase, and ISI web of knowledge databases for papers published before 1 October 2016 was conducted. Summary odds ratios (ORs) with corresponding 95 % confidence intervals (95 %CIs) were estimated, with fixed-effects or random-effects models when appropriate, to assess any association. RESULTS: A total of 9,434 cases and 10,497 controls from 18 studies were included in this meta-analysis. When the eligible studies were pooled, there was no evidence found for a significant association between the hOGG1 Ser326Cys polymorphism and BC in in all genetic contrast models G vs. C (OR=1.19, 95% CI 0.92– 1.53), CG vs. CC (OR = 0.97, 95% CI 0.91-1.04, p = 0.46), GG vs. CC (OR = 1.11, 95% CI 0.91-1.35, p = 0.30), GG + CG vs. CC (OR = 0.98, 95% CI 0.92-1.05, p = 0.67), and GG vs. CG + CC (OR = 1.22, 95% CI 0.98-1.52, p = 0.07). According to subgroup analysis, we also did not find a significant association between the hOGG1 Ser326Cys polymorphism and BC risk in Asians and Caucasians considered separately. CONCLUSIONS: The current meta-analysis suggests that the hOGG1 Ser326Cys polymorphism is not significantly associated with BC risk.
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spelling pubmed-55631082017-08-28 Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies Kamali, Mahdieh Kargar, Saeed Heiranizadeh, Naeimeh Zare, Mohammad Kargar, Shadi Shehneh, Masoud Zare Neamatzadeh, Hossein Asian Pac J Cancer Prev Research Article BACKGROUND: The human 8-oxoguanine DNA glycosylase (hOGG1) gene may be linked with cancer susceptibility. The aim of this study was to quantitatively summarize any association between the hOGG1 Ser326Cys polymorphism and breast cancer (BC) risk. MATERIALS AND METHODS: A comprehensive search of the PubMed, Embase, and ISI web of knowledge databases for papers published before 1 October 2016 was conducted. Summary odds ratios (ORs) with corresponding 95 % confidence intervals (95 %CIs) were estimated, with fixed-effects or random-effects models when appropriate, to assess any association. RESULTS: A total of 9,434 cases and 10,497 controls from 18 studies were included in this meta-analysis. When the eligible studies were pooled, there was no evidence found for a significant association between the hOGG1 Ser326Cys polymorphism and BC in in all genetic contrast models G vs. C (OR=1.19, 95% CI 0.92– 1.53), CG vs. CC (OR = 0.97, 95% CI 0.91-1.04, p = 0.46), GG vs. CC (OR = 1.11, 95% CI 0.91-1.35, p = 0.30), GG + CG vs. CC (OR = 0.98, 95% CI 0.92-1.05, p = 0.67), and GG vs. CG + CC (OR = 1.22, 95% CI 0.98-1.52, p = 0.07). According to subgroup analysis, we also did not find a significant association between the hOGG1 Ser326Cys polymorphism and BC risk in Asians and Caucasians considered separately. CONCLUSIONS: The current meta-analysis suggests that the hOGG1 Ser326Cys polymorphism is not significantly associated with BC risk. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5563108/ /pubmed/28240527 http://dx.doi.org/10.22034/APJCP.2017.18.1.245 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Kamali, Mahdieh
Kargar, Saeed
Heiranizadeh, Naeimeh
Zare, Mohammad
Kargar, Shadi
Shehneh, Masoud Zare
Neamatzadeh, Hossein
Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
title Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
title_full Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
title_fullStr Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
title_full_unstemmed Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
title_short Lack of any Association between the Hogg1 Ser326Cys Polymorphism and Breast Cancer Risk: a Systematic Review And Meta-Analysis Of 18 Studies
title_sort lack of any association between the hogg1 ser326cys polymorphism and breast cancer risk: a systematic review and meta-analysis of 18 studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563108/
https://www.ncbi.nlm.nih.gov/pubmed/28240527
http://dx.doi.org/10.22034/APJCP.2017.18.1.245
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