Fast assembling of neuron fragments in serial 3D sections

Reconstructing neurons from 3D image-stacks of serial sections of thick brain tissue is very time-consuming and often becomes a bottleneck in high-throughput brain mapping projects. We developed NeuronStitcher, a software suite for stitching non-overlapping neuron fragments reconstructed in serial 3...

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Detalles Bibliográficos
Autores principales: Chen, Hanbo, Iascone, Daniel Maxim, da Costa, Nuno Maçarico, Lein, Ed S., Liu, Tianming, Peng, Hanchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563299/
https://www.ncbi.nlm.nih.gov/pubmed/28365869
http://dx.doi.org/10.1007/s40708-017-0063-9
Descripción
Sumario:Reconstructing neurons from 3D image-stacks of serial sections of thick brain tissue is very time-consuming and often becomes a bottleneck in high-throughput brain mapping projects. We developed NeuronStitcher, a software suite for stitching non-overlapping neuron fragments reconstructed in serial 3D image sections. With its efficient algorithm and user-friendly interface, NeuronStitcher has been used successfully to reconstruct very large and complex human and mouse neurons. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40708-017-0063-9) contains supplementary material, which is available to authorized users.

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