Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors

Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia. Recent data show that postsynaptic P2X receptors underlie slow...

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Detalles Bibliográficos
Autores principales: Boué-Grabot, Eric, Pankratov, Yuriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563405/
https://www.ncbi.nlm.nih.gov/pubmed/28845311
http://dx.doi.org/10.1155/2017/9454275
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author Boué-Grabot, Eric
Pankratov, Yuriy
author_facet Boué-Grabot, Eric
Pankratov, Yuriy
author_sort Boué-Grabot, Eric
collection PubMed
description Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia. Recent data show that postsynaptic P2X receptors underlie slow neuromodulatory actions rather than fast synaptic transmission at brain synapses. Here, we review these findings with a particular focus on the release of ATP by astrocytes and the diversity of postsynaptic P2X-mediated modulation of synaptic strength and plasticity in the CNS.
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spelling pubmed-55634052017-08-27 Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors Boué-Grabot, Eric Pankratov, Yuriy Neural Plast Review Article Communication between neuronal and glial cells is important for neural plasticity. P2X receptors are ATP-gated cation channels widely expressed in the brain where they mediate action of extracellular ATP released by neurons and/or glia. Recent data show that postsynaptic P2X receptors underlie slow neuromodulatory actions rather than fast synaptic transmission at brain synapses. Here, we review these findings with a particular focus on the release of ATP by astrocytes and the diversity of postsynaptic P2X-mediated modulation of synaptic strength and plasticity in the CNS. Hindawi 2017 2017-08-06 /pmc/articles/PMC5563405/ /pubmed/28845311 http://dx.doi.org/10.1155/2017/9454275 Text en Copyright © 2017 Eric Boué-Grabot and Yuriy Pankratov. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Boué-Grabot, Eric
Pankratov, Yuriy
Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
title Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
title_full Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
title_fullStr Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
title_full_unstemmed Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
title_short Modulation of Central Synapses by Astrocyte-Released ATP and Postsynaptic P2X Receptors
title_sort modulation of central synapses by astrocyte-released atp and postsynaptic p2x receptors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563405/
https://www.ncbi.nlm.nih.gov/pubmed/28845311
http://dx.doi.org/10.1155/2017/9454275
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