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Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations
The prevalence of Type II Diabetes (T2D) has been increasing and has become a disease of significant public health burden in Jordan. None of the previous genome-wide association studies (GWAS) have specifically investigated the Middle East populations. The Circassian and Chechen communities in Jorda...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563445/ https://www.ncbi.nlm.nih.gov/pubmed/28828242 http://dx.doi.org/10.7717/peerj.3618 |
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author | Dajani, Rana Li, Jin Wei, Zhi March, Michael E. Xia, Qianghua Khader, Yousef Hakooz, Nancy Fatahallah, Raja El-Khateeb, Mohammed Arafat, Ala Saleh, Tareq Dajani, Abdel Rahman Al-Abbadi, Zaid Abdul Qader, Mohamed Shiyab, Abdel Halim Bateiha, Anwar Ajlouni, Kamel Hakonarson, Hakon |
author_facet | Dajani, Rana Li, Jin Wei, Zhi March, Michael E. Xia, Qianghua Khader, Yousef Hakooz, Nancy Fatahallah, Raja El-Khateeb, Mohammed Arafat, Ala Saleh, Tareq Dajani, Abdel Rahman Al-Abbadi, Zaid Abdul Qader, Mohamed Shiyab, Abdel Halim Bateiha, Anwar Ajlouni, Kamel Hakonarson, Hakon |
author_sort | Dajani, Rana |
collection | PubMed |
description | The prevalence of Type II Diabetes (T2D) has been increasing and has become a disease of significant public health burden in Jordan. None of the previous genome-wide association studies (GWAS) have specifically investigated the Middle East populations. The Circassian and Chechen communities in Jordan represent unique populations that are genetically distinct from the Arab population and other populations in the Caucasus. Prevalence of T2D is very high in both the Circassian and Chechen communities in Jordan despite low obesity prevalence. We conducted GWAS on T2D in these two populations and further performed meta-analysis of the results. We identified a novel T2D locus at chr20p12.2 at genome-wide significance (rs6134031, P = 1.12 × 10(−8)) and we replicated the results in the Wellcome Trust Case Control Consortium (WTCCC) dataset. Another locus at chr12q24.31 is associated with T2D at suggestive significance level (top SNP rs4758690, P = 4.20 × 10(−5)) and it is a robust eQTL for the gene, MLXIP (P = 1.10 × 10(−14)), and is significantly associated with methylation level in MLXIP, the functions of which involves cellular glucose response. Therefore, in this first GWAS of T2D in Jordan subpopulations, we identified novel and unique susceptibility loci which may help inform the genetic underpinnings of T2D in other populations. |
format | Online Article Text |
id | pubmed-5563445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55634452017-08-21 Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations Dajani, Rana Li, Jin Wei, Zhi March, Michael E. Xia, Qianghua Khader, Yousef Hakooz, Nancy Fatahallah, Raja El-Khateeb, Mohammed Arafat, Ala Saleh, Tareq Dajani, Abdel Rahman Al-Abbadi, Zaid Abdul Qader, Mohamed Shiyab, Abdel Halim Bateiha, Anwar Ajlouni, Kamel Hakonarson, Hakon PeerJ Genetics The prevalence of Type II Diabetes (T2D) has been increasing and has become a disease of significant public health burden in Jordan. None of the previous genome-wide association studies (GWAS) have specifically investigated the Middle East populations. The Circassian and Chechen communities in Jordan represent unique populations that are genetically distinct from the Arab population and other populations in the Caucasus. Prevalence of T2D is very high in both the Circassian and Chechen communities in Jordan despite low obesity prevalence. We conducted GWAS on T2D in these two populations and further performed meta-analysis of the results. We identified a novel T2D locus at chr20p12.2 at genome-wide significance (rs6134031, P = 1.12 × 10(−8)) and we replicated the results in the Wellcome Trust Case Control Consortium (WTCCC) dataset. Another locus at chr12q24.31 is associated with T2D at suggestive significance level (top SNP rs4758690, P = 4.20 × 10(−5)) and it is a robust eQTL for the gene, MLXIP (P = 1.10 × 10(−14)), and is significantly associated with methylation level in MLXIP, the functions of which involves cellular glucose response. Therefore, in this first GWAS of T2D in Jordan subpopulations, we identified novel and unique susceptibility loci which may help inform the genetic underpinnings of T2D in other populations. PeerJ Inc. 2017-08-17 /pmc/articles/PMC5563445/ /pubmed/28828242 http://dx.doi.org/10.7717/peerj.3618 Text en ©2017 Dajani et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Genetics Dajani, Rana Li, Jin Wei, Zhi March, Michael E. Xia, Qianghua Khader, Yousef Hakooz, Nancy Fatahallah, Raja El-Khateeb, Mohammed Arafat, Ala Saleh, Tareq Dajani, Abdel Rahman Al-Abbadi, Zaid Abdul Qader, Mohamed Shiyab, Abdel Halim Bateiha, Anwar Ajlouni, Kamel Hakonarson, Hakon Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations |
title | Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations |
title_full | Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations |
title_fullStr | Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations |
title_full_unstemmed | Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations |
title_short | Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations |
title_sort | genome-wide association study identifies novel type ii diabetes risk loci in jordan subpopulations |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563445/ https://www.ncbi.nlm.nih.gov/pubmed/28828242 http://dx.doi.org/10.7717/peerj.3618 |
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