Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer

The proto-oncogene PTTG and its binding partner PBF have been widely studied in multiple cancer types, particularly thyroid and colorectal, but their combined role in tumourigenesis is uncharacterised. Here, we show for the first time that together PTTG and PBF significantly modulate DNA damage resp...

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Detalles Bibliográficos
Autores principales: Read, Martin L., Fong, Jim C.W., Modasia, Bhavika, Fletcher, Alice, Imruetaicharoenchoke, Waraporn, Thompson, Rebecca, Nieto, Hannah, Reynolds, John J., Bacon, Andrea, Mallick, Ujjal, Hackshaw, Allan, Watkinson, John C., Boelaert, Kristien, Turnell, Andrew S., Smith, Vicki E., McCabe, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563453/
https://www.ncbi.nlm.nih.gov/pubmed/28504713
http://dx.doi.org/10.1038/onc.2017.154

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