Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide

PURPOSE: Age-related macular degeneration (AMD) is the leading cause of permanent vision loss among the elderly in many industrialized countries, and the complement system plays an important role in the pathogenesis of AMD. Inhibition of complement factor B, a key regulator of the alternative pathwa...

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Detalles Bibliográficos
Autores principales: Grossman, Tamar R., Carrer, Michele, Shen, Lijiang, Johnson, Robert B., Hettrick, Lisa A., Henry, Scott P., Monia, Brett P., McCaleb, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563462/
https://www.ncbi.nlm.nih.gov/pubmed/28855795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563462/
https://www.ncbi.nlm.nih.gov/pubmed/28855795

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