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Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups
BACKGROUND: Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO as well as the clinical features of EO BD type 1 (BD1) with EO BD type 2 (BD2)....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563503/ https://www.ncbi.nlm.nih.gov/pubmed/28480486 http://dx.doi.org/10.1186/s40345-017-0097-1 |
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author | Manchia, Mirko Maina, Giuseppe Carpiniello, Bernardo Pinna, Federica Steardo, Luca D’Ambrosio, Virginia Salvi, Virginio Alda, Martin Tortorella, Alfonso Albert, Umberto |
author_facet | Manchia, Mirko Maina, Giuseppe Carpiniello, Bernardo Pinna, Federica Steardo, Luca D’Ambrosio, Virginia Salvi, Virginio Alda, Martin Tortorella, Alfonso Albert, Umberto |
author_sort | Manchia, Mirko |
collection | PubMed |
description | BACKGROUND: Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO as well as the clinical features of EO BD type 1 (BD1) with EO BD type 2 (BD2). To this end, we studied 515 BD patients (224 BD1, 279 BD2, and 12 BD not otherwise specified [NOS]) diagnosed according to DSM-IV-TR criteria. METHODS: AAO was defined as the first reliably diagnosed hypo/manic or depressive episode according to diagnostic criteria. We used normal distribution mixture analysis to identify subgroups of patients according to AAO. Models were chosen according to the Schwarz’s Bayesian information criteria (BIC). Clinical correlates of EO were analysed using univariate tests and multivariate logistic regression models. RESULTS: A two normal components model best fitted the observed distribution of AAO in BD1 (BIC = −1599.3), BD2 (BIC = −2158.4), and in the whole sample (BIC = −3854.9). A higher number of EO BD2 patients had a depression-(hypo)mania-free interval (DMI) course, while a higher rate of (hypo)mania-depression-free interval (MDI) course was found in EO BD1. EO BD2 had also a higher rate of comorbidity with alcohol dependence compared to EO BD1. The latter finding was confirmed by multivariate logistic regression analysis. CONCLUSIONS: In conclusion, both BD1 and BD2 had bimodal AAO distributions, but EO subgroups had a diagnostic-specific clinical delineation. |
format | Online Article Text |
id | pubmed-5563503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-55635032017-09-06 Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups Manchia, Mirko Maina, Giuseppe Carpiniello, Bernardo Pinna, Federica Steardo, Luca D’Ambrosio, Virginia Salvi, Virginio Alda, Martin Tortorella, Alfonso Albert, Umberto Int J Bipolar Disord Research BACKGROUND: Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO as well as the clinical features of EO BD type 1 (BD1) with EO BD type 2 (BD2). To this end, we studied 515 BD patients (224 BD1, 279 BD2, and 12 BD not otherwise specified [NOS]) diagnosed according to DSM-IV-TR criteria. METHODS: AAO was defined as the first reliably diagnosed hypo/manic or depressive episode according to diagnostic criteria. We used normal distribution mixture analysis to identify subgroups of patients according to AAO. Models were chosen according to the Schwarz’s Bayesian information criteria (BIC). Clinical correlates of EO were analysed using univariate tests and multivariate logistic regression models. RESULTS: A two normal components model best fitted the observed distribution of AAO in BD1 (BIC = −1599.3), BD2 (BIC = −2158.4), and in the whole sample (BIC = −3854.9). A higher number of EO BD2 patients had a depression-(hypo)mania-free interval (DMI) course, while a higher rate of (hypo)mania-depression-free interval (MDI) course was found in EO BD1. EO BD2 had also a higher rate of comorbidity with alcohol dependence compared to EO BD1. The latter finding was confirmed by multivariate logistic regression analysis. CONCLUSIONS: In conclusion, both BD1 and BD2 had bimodal AAO distributions, but EO subgroups had a diagnostic-specific clinical delineation. Springer Berlin Heidelberg 2017-08-21 /pmc/articles/PMC5563503/ /pubmed/28480486 http://dx.doi.org/10.1186/s40345-017-0097-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Manchia, Mirko Maina, Giuseppe Carpiniello, Bernardo Pinna, Federica Steardo, Luca D’Ambrosio, Virginia Salvi, Virginio Alda, Martin Tortorella, Alfonso Albert, Umberto Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
title | Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
title_full | Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
title_fullStr | Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
title_full_unstemmed | Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
title_short | Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
title_sort | clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563503/ https://www.ncbi.nlm.nih.gov/pubmed/28480486 http://dx.doi.org/10.1186/s40345-017-0097-1 |
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