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Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia
A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lym...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563554/ https://www.ncbi.nlm.nih.gov/pubmed/28845330 http://dx.doi.org/10.4274/tjo.80557 |
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author | Koban, Yaran Özlece, Hatice Ayar, Orhan Koç, Mustafa Çelik, Hüseyin Yazar, Zeliha Burcu, Ayşe |
author_facet | Koban, Yaran Özlece, Hatice Ayar, Orhan Koç, Mustafa Çelik, Hüseyin Yazar, Zeliha Burcu, Ayşe |
author_sort | Koban, Yaran |
collection | PubMed |
description | A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lymphoma. Cytology later showed the presence of mantle cells in cerebrospinal fluid analysis. Her ophthalmoplegia improved from her first cycle of systemic and intrathecal chemotherapy. To the best of our knowledge, this is the second case in the literature of mantle cell lymphoma with central nervous system involvement presenting with ophthalmoplegia. This symptom should be considered one of the initial signs of mantle cell lymphoma. |
format | Online Article Text |
id | pubmed-5563554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-55635542017-08-25 Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia Koban, Yaran Özlece, Hatice Ayar, Orhan Koç, Mustafa Çelik, Hüseyin Yazar, Zeliha Burcu, Ayşe Turk J Ophthalmol Case Report A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lymphoma. Cytology later showed the presence of mantle cells in cerebrospinal fluid analysis. Her ophthalmoplegia improved from her first cycle of systemic and intrathecal chemotherapy. To the best of our knowledge, this is the second case in the literature of mantle cell lymphoma with central nervous system involvement presenting with ophthalmoplegia. This symptom should be considered one of the initial signs of mantle cell lymphoma. Galenos Publishing 2017-08 2017-08-15 /pmc/articles/PMC5563554/ /pubmed/28845330 http://dx.doi.org/10.4274/tjo.80557 Text en ©Copyright 2017 by Turkish Ophthalmological Association Turkish Journal of Ophthalmology, published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Koban, Yaran Özlece, Hatice Ayar, Orhan Koç, Mustafa Çelik, Hüseyin Yazar, Zeliha Burcu, Ayşe Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia |
title | Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia |
title_full | Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia |
title_fullStr | Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia |
title_full_unstemmed | Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia |
title_short | Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia |
title_sort | mantle cell lymphoma presenting with acute bilateral ophthalmoplegia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563554/ https://www.ncbi.nlm.nih.gov/pubmed/28845330 http://dx.doi.org/10.4274/tjo.80557 |
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