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Could Eosinophilia predict clinical severity in nasal polyps?
BACKGROUND: Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563888/ https://www.ncbi.nlm.nih.gov/pubmed/28835819 http://dx.doi.org/10.1186/s40248-017-0102-7 |
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author | Aslan, Figen Altun, Eren Paksoy, Serpil Turan, Gulay |
author_facet | Aslan, Figen Altun, Eren Paksoy, Serpil Turan, Gulay |
author_sort | Aslan, Figen |
collection | PubMed |
description | BACKGROUND: Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps. METHODS: The study included 53 patients with nasal polyps who underwent endoscopic sinus surgery. Preoperative Lund-MacKay computed tomography (CT) scores and the Lund-Kennedy endoscopic scores of the patients were recorded. Nasal polyp tissues were stained with hematoxylin and eosin, eosinophil counts were performed using high-power field (HPF, 400×) under the light microscope, and the patients were grouped as those with high mucosal eosinophil count and those with low mucosal eosinophil count. RESULTS: The mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic score were higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count. Likewise, the mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic scores were significantly higher in the patients with high peripheral eosinophil count than in those with low peripheral eosinophil count (p < 0.05 for both). Moreover, the mean peripheral eosinophil count was significantly higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count (p < 0.05). CONCLUSION: Mucosal and peripheral eosinophilia can be used as a marker to predict disease severity in nasal polyps. |
format | Online Article Text |
id | pubmed-5563888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-55638882017-08-23 Could Eosinophilia predict clinical severity in nasal polyps? Aslan, Figen Altun, Eren Paksoy, Serpil Turan, Gulay Multidiscip Respir Med Original Research Article BACKGROUND: Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps. METHODS: The study included 53 patients with nasal polyps who underwent endoscopic sinus surgery. Preoperative Lund-MacKay computed tomography (CT) scores and the Lund-Kennedy endoscopic scores of the patients were recorded. Nasal polyp tissues were stained with hematoxylin and eosin, eosinophil counts were performed using high-power field (HPF, 400×) under the light microscope, and the patients were grouped as those with high mucosal eosinophil count and those with low mucosal eosinophil count. RESULTS: The mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic score were higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count. Likewise, the mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic scores were significantly higher in the patients with high peripheral eosinophil count than in those with low peripheral eosinophil count (p < 0.05 for both). Moreover, the mean peripheral eosinophil count was significantly higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count (p < 0.05). CONCLUSION: Mucosal and peripheral eosinophilia can be used as a marker to predict disease severity in nasal polyps. BioMed Central 2017-08-21 /pmc/articles/PMC5563888/ /pubmed/28835819 http://dx.doi.org/10.1186/s40248-017-0102-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Research Article Aslan, Figen Altun, Eren Paksoy, Serpil Turan, Gulay Could Eosinophilia predict clinical severity in nasal polyps? |
title | Could Eosinophilia predict clinical severity in nasal polyps? |
title_full | Could Eosinophilia predict clinical severity in nasal polyps? |
title_fullStr | Could Eosinophilia predict clinical severity in nasal polyps? |
title_full_unstemmed | Could Eosinophilia predict clinical severity in nasal polyps? |
title_short | Could Eosinophilia predict clinical severity in nasal polyps? |
title_sort | could eosinophilia predict clinical severity in nasal polyps? |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563888/ https://www.ncbi.nlm.nih.gov/pubmed/28835819 http://dx.doi.org/10.1186/s40248-017-0102-7 |
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