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Chromatographic Characterization and Method Development for Determination of Levetiracetam in Saliva: Application to Correlation with Plasma Levels

Levetiracetam (LVT) is a widely used antiepileptic drug (AED). A less invasive sampling method for therapeutic drug monitoring (TDM) would be very useful particularly for children. Saliva has been shown as an adequate sample for TDM of some AEDs. Due to the high hydrophilicity of LVT its separation...

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Detalles Bibliográficos
Autores principales: Hamdan, Imad I., Alsous, Mervat, Masri, Amira Taher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564075/
https://www.ncbi.nlm.nih.gov/pubmed/28848686
http://dx.doi.org/10.1155/2017/7846742