Cargando…

Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway

Bromodomain containing protein 4 (BRD4) has been demonstrated to play a critical role in tumor progression. However, the expression and function of BRD4 in gallbladder cancer (GBC) are still unknown. In this study, we report that BRD4 expression level was significantly upregulated in GBC tissues and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Jiaqi, Yang, Ziyi, Wang, Lei, Zhang, Yijian, Shu, Yijun, Jiang, Lin, Hu, Yunping, Lv, Wenjie, Dong, Ping, Liu, Yingbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564407/ https://www.ncbi.nlm.nih.gov/pubmed/28766687 http://dx.doi.org/10.3892/ijo.2017.4081

Ejemplares similares

Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling
por: Song, Xiaoling, et al.
Publicado: (2017)

TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway
por: Zhang, Yijian, et al.
Publicado: (2020)

BRD4 inhibitor and histone deacetylase inhibitor synergistically inhibit the proliferation of gallbladder cancer in vitro and in vivo
por: Liu, Shilei, et al.
Publicado: (2019)

EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway
por: Zhang, Fei, et al.
Publicado: (2017)

Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells
por: Wang, Jiaqi, et al.
Publicado: (2018)

Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells
por: Ke, Fayong, et al.
Publicado: (2017)

Correction: EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway
por: Zhang, Fei, et al.
Publicado: (2021)

Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer
por: Zhang, Fei, et al.
Publicado: (2017)

Correction to: Dihydroartemisinin inhibits TCTPdependent metastasis in gallbladder cancer
por: Zhang, Fei, et al.
Publicado: (2022)

The PLGF/c‐MYC/miR‐19a axis promotes metastasis and stemness in gallbladder cancer
por: Li, Huaifeng, et al.
Publicado: (2018)

Correction to: Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer
por: Zhang, Fei, et al.
Publicado: (2019)

Role of Sciellin in gallbladder cancer proliferation and formation of neutrophil extracellular traps
por: Li, Yang, et al.
Publicado: (2021)

Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation
por: Zhai, Tianyu, et al.
Publicado: (2021)

TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT
por: Li, Xinxing, et al.
Publicado: (2017)

Corrigendum: Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation
por: Zhai, Tianyu, et al.
Publicado: (2021)

Correction: TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT
por: Li, Xinxing, et al.
Publicado: (2019)

Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis
por: Li, Jiandong, et al.
Publicado: (2022)

Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma
por: Wang, H, et al.
Publicado: (2014)

miR-223 increases gallbladder cancer cell sensitivity to docetaxel by downregulating STMN1
por: Lu, Wei, et al.
Publicado: (2016)

SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway
por: Shu, Yi-Jun, et al.
Publicado: (2015)

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway
por: Li, Wenjun, et al.
Publicado: (2020)

Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway
por: Hu, Binwu, et al.
Publicado: (2017)

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway
por: Bao, Runfa, et al.
Publicado: (2014)

Downregulation of RAGE Inhibits Cell Proliferation and Induces Apoptosis via Regulation of PI3K/AKT Pathway in Cervical Squamous Cell Carcinoma
por: Li, Ruyi, et al.
Publicado: (2020)

Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway
por: Xu, Chaojian, et al.
Publicado: (2022)

Overview of current targeted therapy in gallbladder cancer
por: Song, Xiaoling, et al.
Publicado: (2020)

Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway
por: Qiao, Juan, et al.
Publicado: (2018)

KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer
por: Wei, Dang, et al.
Publicado: (2021)

Downregulation of miR-34a Promotes Proliferation and Inhibits Apoptosis of Rat Osteoarthritic Cartilage Cells by Activating PI3K/Akt Pathway
por: Tao, Haitao, et al.
Publicado: (2020)

Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
por: Chen, Hanyu, et al.
Publicado: (2020)

Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes
por: Sun, Xiaohui, et al.
Publicado: (2021)

TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway
por: Chen, Liuyan, et al.
Publicado: (2022)

Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells
por: Chen, Kunlun, et al.
Publicado: (2021)

Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway
por: Tong, Chenhao, et al.
Publicado: (2021)

Azoxystrobin induces apoptosis via PI3K/AKT and MAPK signal pathways in oral leukoplakia progression
por: Li, Lingyu, et al.
Publicado: (2022)

MicroRNA-608 promotes apoptosis via BRD4 downregulation in pancreatic ductal adenocarcinoma
por: Li, Maoyuan, et al.
Publicado: (2020)

FOXK1 Promotes Proliferation and Metastasis of Gallbladder Cancer by Activating AKT/mTOR Signaling Pathway
por: Wencong, Ma, et al.
Publicado: (2020)

Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder
por: Liu, Fatao, et al.
Publicado: (2021)

BRD4 Inhibition Protects Against Myocardial Ischemia/Reperfusion Injury by Suppressing Inflammation and Oxidative Stress Through the PI3K/AKT Signaling Pathway
por: Wei, Hongwei, et al.
Publicado: (2021)

Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma
por: Vann, Kendra R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s2q4pli27u140mgdde7hpuqj5n