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Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells
MCL-1 (BCL-2 family anti-apoptotic protein) is responsible for melanoma's resistance to therapy. Cancer initiating cells also contribute to resistance and relapse from treatments. Here we examined the effects of the MCL-1 inhibitor SC-2001 in killing non melanoma-initiating-cells (bulk of melan...
Autores principales: | Mukherjee, Nabanita, Lu, Yan, Almeida, Adam, Lambert, Karoline, Shiau, Chung-Wai, Su, Jung-Chen, Luo, Yuchun, Fujita, Mayumi, Robinson, William A., Robinson, Steven E., Norris, David A., Shellman, Yiqun G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564524/ https://www.ncbi.nlm.nih.gov/pubmed/27086916 http://dx.doi.org/10.18632/oncotarget.8695 |
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