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Effects of renal denervation on monocrotaline induced pulmonary remodeling

Pulmonary artery hypertension (PAH) is a rapidly progressive disorder, which leads to right heart failure and even death. Overactivity of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system accounts for the development and progression of PAH. The role of renal denervation...

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Autores principales: Liu, Qian, Song, Jiyang, Lu, Dasheng, Geng, Jie, Jiang, Zhixin, Wang, Kai, Zhang, Bin, Shan, Qijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564527/
https://www.ncbi.nlm.nih.gov/pubmed/28187460
http://dx.doi.org/10.18632/oncotarget.15154
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author Liu, Qian
Song, Jiyang
Lu, Dasheng
Geng, Jie
Jiang, Zhixin
Wang, Kai
Zhang, Bin
Shan, Qijun
author_facet Liu, Qian
Song, Jiyang
Lu, Dasheng
Geng, Jie
Jiang, Zhixin
Wang, Kai
Zhang, Bin
Shan, Qijun
author_sort Liu, Qian
collection PubMed
description Pulmonary artery hypertension (PAH) is a rapidly progressive disorder, which leads to right heart failure and even death. Overactivity of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system accounts for the development and progression of PAH. The role of renal denervation (RDN) in different periods of PAH has not been fully elucidated. A single intraperitoneal injection of monocrotaline (MCT, 60 mg/kg) was used to induce pulmonary remodeling in male Sprague Dawley rats (n = 40). After 24-hour of MCT administration, a subset of rats underwent RDN (RDN(24h), n = 10); after 2-week of MCT injection, another ten rats received RDN treatment (RDN(2w), n = 10) and the left 20 rats were divided to MCT group with sham RDN operation (MCT, n = 20). Eight rats in Control group received intraperitoneal injection of normal saline (60 mg/kg) once and sham RDN surgery. After 35 days, tissue and blood samples were collected. Histological analysis demonstrated that the collagen volume fraction of right ventricle, lung tissue and pulmonary vessel reduced significantly in RDN(24h) group but not in the RDN2w group, compared with MCT group. Moreover, the earlier RDN treatment significantly decreased SNS activity and blunted RAAS activation. Importantly, RDN treatment significantly improved the survival rate. In summary, earlier RDN treatment could attenuate cardio-pulmonary fibrosis and therefore might be a promising approach to prevent the development of PAH.
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spelling pubmed-55645272017-08-23 Effects of renal denervation on monocrotaline induced pulmonary remodeling Liu, Qian Song, Jiyang Lu, Dasheng Geng, Jie Jiang, Zhixin Wang, Kai Zhang, Bin Shan, Qijun Oncotarget Research Paper Pulmonary artery hypertension (PAH) is a rapidly progressive disorder, which leads to right heart failure and even death. Overactivity of the renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system accounts for the development and progression of PAH. The role of renal denervation (RDN) in different periods of PAH has not been fully elucidated. A single intraperitoneal injection of monocrotaline (MCT, 60 mg/kg) was used to induce pulmonary remodeling in male Sprague Dawley rats (n = 40). After 24-hour of MCT administration, a subset of rats underwent RDN (RDN(24h), n = 10); after 2-week of MCT injection, another ten rats received RDN treatment (RDN(2w), n = 10) and the left 20 rats were divided to MCT group with sham RDN operation (MCT, n = 20). Eight rats in Control group received intraperitoneal injection of normal saline (60 mg/kg) once and sham RDN surgery. After 35 days, tissue and blood samples were collected. Histological analysis demonstrated that the collagen volume fraction of right ventricle, lung tissue and pulmonary vessel reduced significantly in RDN(24h) group but not in the RDN2w group, compared with MCT group. Moreover, the earlier RDN treatment significantly decreased SNS activity and blunted RAAS activation. Importantly, RDN treatment significantly improved the survival rate. In summary, earlier RDN treatment could attenuate cardio-pulmonary fibrosis and therefore might be a promising approach to prevent the development of PAH. Impact Journals LLC 2017-02-07 /pmc/articles/PMC5564527/ /pubmed/28187460 http://dx.doi.org/10.18632/oncotarget.15154 Text en Copyright: © 2017 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liu, Qian
Song, Jiyang
Lu, Dasheng
Geng, Jie
Jiang, Zhixin
Wang, Kai
Zhang, Bin
Shan, Qijun
Effects of renal denervation on monocrotaline induced pulmonary remodeling
title Effects of renal denervation on monocrotaline induced pulmonary remodeling
title_full Effects of renal denervation on monocrotaline induced pulmonary remodeling
title_fullStr Effects of renal denervation on monocrotaline induced pulmonary remodeling
title_full_unstemmed Effects of renal denervation on monocrotaline induced pulmonary remodeling
title_short Effects of renal denervation on monocrotaline induced pulmonary remodeling
title_sort effects of renal denervation on monocrotaline induced pulmonary remodeling
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564527/
https://www.ncbi.nlm.nih.gov/pubmed/28187460
http://dx.doi.org/10.18632/oncotarget.15154
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