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Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer

PR domain zinc finger protein 14 (PRDM14) maintains stemness in embryonic stem cells via epigenetic mechanisms. Although PRDM14 is elevated in several cancers, it is unclear if and how PRDM14 confers stem cell-like properties and epigenetic changes to cancer cells. Here, we examined the phenotypic c...

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Detalles Bibliográficos
Autores principales:	Taniguchi, Hiroaki, Hoshino, Daisuke, Moriya, Chiharu, Zembutsu, Hitoshi, Nishiyama, Nobuhiro, Yamamoto, Hiroyuki, Kataoka, Kazunori, Imai, Kohzoh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564528/ https://www.ncbi.nlm.nih.gov/pubmed/28423353 http://dx.doi.org/10.18632/oncotarget.16776

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