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MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)

A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model. Seven weeks after implantation, PDOX nude mice were divided into the following groups: untreated control (n = 7); g...

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Detalles Bibliográficos
Autores principales:	Kawaguchi, Kei, Igarashi, Kentaro, Murakami, Takashi, Kiyuna, Tasuku, Lwin, Thinzar M., Hwang, Ho Kyoung, Delong, Jonathan C., Clary, Bryan M., Bouvet, Michael, Unno, Michiaki, Hoffman, Robert M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564580/ https://www.ncbi.nlm.nih.gov/pubmed/28537897 http://dx.doi.org/10.18632/oncotarget.17667

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