Cullin 3(SPOP) ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6

The histone deacetylase 6 (HDAC6) plays critical roles in human tumorigenesis and metastasis. As such, HDAC6-selective inhibitors have entered clinical trials for cancer therapy. However, the upstream regulator(s), especially ubiquitin E3 ligase(s), responsible for controlling the protein stability...

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Detalles Bibliográficos
Autores principales: Tan, Yuyong, Ci, Yanpeng, Dai, Xiangpeng, Wu, Fei, Guo, Jianping, Liu, Deliang, North, Brian J., Huo, Jirong, Zhang, Jinfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564613/
https://www.ncbi.nlm.nih.gov/pubmed/28599312
http://dx.doi.org/10.18632/oncotarget.18141

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