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mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer

Activation of Wnt/β-catenin signaling is essential for colorectal carcinogenesis. Tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, is a positive regulator of the Wnt/β-catenin signaling. Accordingly, tankyrase inhibitors are under preclinical development for colorectal cancer (C...

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Detalles Bibliográficos
Autores principales:	Mashima, Tetsuo, Taneda, Yoko, Jang, Myung-Kyu, Mizutani, Anna, Muramatsu, Yukiko, Yoshida, Haruka, Sato, Ayana, Tanaka, Noritaka, Sugimoto, Yoshikazu, Seimiya, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564614/ https://www.ncbi.nlm.nih.gov/pubmed/28615517 http://dx.doi.org/10.18632/oncotarget.18146

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