SNM1B/Apollo in the DNA damage response and telomere maintenance

hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also v...

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Detalles Bibliográficos
Autores principales: Schmiester, Maren, Demuth, Ilja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564657/
https://www.ncbi.nlm.nih.gov/pubmed/28430596
http://dx.doi.org/10.18632/oncotarget.16864
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author Schmiester, Maren
Demuth, Ilja
author_facet Schmiester, Maren
Demuth, Ilja
author_sort Schmiester, Maren
collection PubMed
description hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also vital for the generation and maintenance of telomeric overhangs. In this review, we will summarize studies on hSNM1B/Apollo's function, including its contribution to DNA damage signaling, replication fork maintenance, control of topological stress and telomere protection. Furthermore, we will highlight recent studies illustrating hSNM1B/Apollo's putative role in human disease.
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spelling pubmed-55646572017-08-23 SNM1B/Apollo in the DNA damage response and telomere maintenance Schmiester, Maren Demuth, Ilja Oncotarget Review hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also vital for the generation and maintenance of telomeric overhangs. In this review, we will summarize studies on hSNM1B/Apollo's function, including its contribution to DNA damage signaling, replication fork maintenance, control of topological stress and telomere protection. Furthermore, we will highlight recent studies illustrating hSNM1B/Apollo's putative role in human disease. Impact Journals LLC 2017-04-05 /pmc/articles/PMC5564657/ /pubmed/28430596 http://dx.doi.org/10.18632/oncotarget.16864 Text en Copyright: © 2017 Schmiester and Demuth http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Schmiester, Maren
Demuth, Ilja
SNM1B/Apollo in the DNA damage response and telomere maintenance
title SNM1B/Apollo in the DNA damage response and telomere maintenance
title_full SNM1B/Apollo in the DNA damage response and telomere maintenance
title_fullStr SNM1B/Apollo in the DNA damage response and telomere maintenance
title_full_unstemmed SNM1B/Apollo in the DNA damage response and telomere maintenance
title_short SNM1B/Apollo in the DNA damage response and telomere maintenance
title_sort snm1b/apollo in the dna damage response and telomere maintenance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564657/
https://www.ncbi.nlm.nih.gov/pubmed/28430596
http://dx.doi.org/10.18632/oncotarget.16864
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