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Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth

Acetyl-CoA carboxylase (ACC) is the rate-limiting enzyme in de novo fatty acid synthesis, and its ACC1 isoform is overexpressed in pancreatic and various other cancers. The activity of many oncogenic signaling molecules, including WNT and Hedgehog (HH), is post-translationally modified by lipidation...

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Detalles Bibliográficos
Autores principales:	Petrova, Elissaveta, Scholz, Arne, Paul, Juliane, Sturz, Andrea, Haike, Katja, Siegel, Franziska, Mumberg, Dominik, Liu, Ningshu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564715/ https://www.ncbi.nlm.nih.gov/pubmed/27750213 http://dx.doi.org/10.18632/oncotarget.12650

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