Histone demethylase JMJD3 regulates CD11a expression through changes in histone H3K27 tri-methylation levels in CD4(+) T cells of patients with systemic lupus erythematosus

Aberrant CD11a overexpression in CD4(+) T cells induces T cell auto-reactivity, which is an important factor for systemic lupus erythematosus (SLE) pathogenesis. Although many studies have focused on CD11a epigenetic regulation, little is known about histone methylation. JMJD3, as a histone demethyl...

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Detalles Bibliográficos
Autores principales: Yin, Heng, Wu, Haijing, Zhao, Ming, Zhang, Qing, Long, Hai, Fu, Siqi, Lu, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564738/
https://www.ncbi.nlm.nih.gov/pubmed/28430662
http://dx.doi.org/10.18632/oncotarget.16894

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