Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration

Nitrosative stress has been implicated in the pathogenesis of age related macular degeneration (AMD). Tyrosine nitration is a unique type of post translational modification that occurs in the setting of inflammation and nitrosative stress. To date, the significance and functional implications of tyr...

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Detalles Bibliográficos
Autores principales: Krilis, Matthew, Qi, Miao, Madigan, Michele C., Wong, Jason W. H., Abdelatti, Mahmoud, Guymer, Robyn H., Whitelock, John, McCluskey, Peter, Zhang, Peng, Qi, Jian, Hunyor, Alex P., Krilis, Steven A., Giannakopoulos, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564745/
https://www.ncbi.nlm.nih.gov/pubmed/28159936
http://dx.doi.org/10.18632/oncotarget.14940

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