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Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression
Transforming growth factor-β1 is considered a key contributor to the progression of breast cancer. MicroRNAs are important factors in the development and progression of many malignancies. In the present study, upon studies of breast cancer cell lines and tissues, we showed that microRNA -196a-3p is...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564753/ https://www.ncbi.nlm.nih.gov/pubmed/28418877 http://dx.doi.org/10.18632/oncotarget.16308 |
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author | Chen, Yan Huang, Shai Wu, Bo Fang, Jiankai Zhu, Minsheng Sun, Li Zhang, Lifeng Zhang, Yongsheng Sun, Maomin Guo, Lingling Wang, Shouli |
author_facet | Chen, Yan Huang, Shai Wu, Bo Fang, Jiankai Zhu, Minsheng Sun, Li Zhang, Lifeng Zhang, Yongsheng Sun, Maomin Guo, Lingling Wang, Shouli |
author_sort | Chen, Yan |
collection | PubMed |
description | Transforming growth factor-β1 is considered a key contributor to the progression of breast cancer. MicroRNAs are important factors in the development and progression of many malignancies. In the present study, upon studies of breast cancer cell lines and tissues, we showed that microRNA -196a-3p is decreased by transforming growth factor-β1 in breast cancer cells and associated with breast cancer progression. We identified neuropilin-2 as a target gene of microRNA -196a-3p and showed that it is regulated by transforming growth factor-β1. Moreover, transforming growth factor-β1-mediated inhibition of microRNA -196a-3p and activation of neuropilin-2were required for transforming growth factor-β1-induced migration and invasion of breast cancer cells. In addition, neuropilin-2 expression was suppressed in breast tumors, particularly in triple-negative breast cancers. Collectively, our findings strongly indicate that microRNA -196a-3p is a predictive biomarker of breast cancer metastasis and patient survival and a potential therapeutic target in metastatic breast cancer. |
format | Online Article Text |
id | pubmed-5564753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55647532017-08-23 Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression Chen, Yan Huang, Shai Wu, Bo Fang, Jiankai Zhu, Minsheng Sun, Li Zhang, Lifeng Zhang, Yongsheng Sun, Maomin Guo, Lingling Wang, Shouli Oncotarget Research Paper Transforming growth factor-β1 is considered a key contributor to the progression of breast cancer. MicroRNAs are important factors in the development and progression of many malignancies. In the present study, upon studies of breast cancer cell lines and tissues, we showed that microRNA -196a-3p is decreased by transforming growth factor-β1 in breast cancer cells and associated with breast cancer progression. We identified neuropilin-2 as a target gene of microRNA -196a-3p and showed that it is regulated by transforming growth factor-β1. Moreover, transforming growth factor-β1-mediated inhibition of microRNA -196a-3p and activation of neuropilin-2were required for transforming growth factor-β1-induced migration and invasion of breast cancer cells. In addition, neuropilin-2 expression was suppressed in breast tumors, particularly in triple-negative breast cancers. Collectively, our findings strongly indicate that microRNA -196a-3p is a predictive biomarker of breast cancer metastasis and patient survival and a potential therapeutic target in metastatic breast cancer. Impact Journals LLC 2017-03-17 /pmc/articles/PMC5564753/ /pubmed/28418877 http://dx.doi.org/10.18632/oncotarget.16308 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Chen, Yan Huang, Shai Wu, Bo Fang, Jiankai Zhu, Minsheng Sun, Li Zhang, Lifeng Zhang, Yongsheng Sun, Maomin Guo, Lingling Wang, Shouli Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression |
title | Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression |
title_full | Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression |
title_fullStr | Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression |
title_full_unstemmed | Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression |
title_short | Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression |
title_sort | transforming growth factor-β1 promotes breast cancer metastasis by downregulating mir-196a-3p expression |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564753/ https://www.ncbi.nlm.nih.gov/pubmed/28418877 http://dx.doi.org/10.18632/oncotarget.16308 |
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