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Integration of phytochemicals and phytotherapy into cancer precision medicine
Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564849/ https://www.ncbi.nlm.nih.gov/pubmed/28514737 http://dx.doi.org/10.18632/oncotarget.17466 |
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author | Efferth, Thomas Saeed, Mohamed E.M. Mirghani, Elhaj Alim, Awadh Yassin, Zahir Saeed, Elfatih Khalid, Hassan E. Daak, Salah |
author_facet | Efferth, Thomas Saeed, Mohamed E.M. Mirghani, Elhaj Alim, Awadh Yassin, Zahir Saeed, Elfatih Khalid, Hassan E. Daak, Salah |
author_sort | Efferth, Thomas |
collection | PubMed |
description | Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multi-specifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phytochemicals and phytotherapy into academic western medicine. Modern technology platforms (e.g. “-omics” technologies, DNA/RNA sequencing, and network pharmacology) can be applied for diverse treatment modalities such as cytotoxic and targeted chemotherapy as well as phytochemicals and phytotherapy. Thereby, these technologies represent an integrative momentum to merge the best of two worlds: clinical oncology and traditional medicine. In conclusion, the integration of phytochemicals and phytotherapy into cancer precision medicine represents a valuable asset to chemically synthesized chemicals and therapeutic antibodies. |
format | Online Article Text |
id | pubmed-5564849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55648492017-08-23 Integration of phytochemicals and phytotherapy into cancer precision medicine Efferth, Thomas Saeed, Mohamed E.M. Mirghani, Elhaj Alim, Awadh Yassin, Zahir Saeed, Elfatih Khalid, Hassan E. Daak, Salah Oncotarget Review Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multi-specifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phytochemicals and phytotherapy into academic western medicine. Modern technology platforms (e.g. “-omics” technologies, DNA/RNA sequencing, and network pharmacology) can be applied for diverse treatment modalities such as cytotoxic and targeted chemotherapy as well as phytochemicals and phytotherapy. Thereby, these technologies represent an integrative momentum to merge the best of two worlds: clinical oncology and traditional medicine. In conclusion, the integration of phytochemicals and phytotherapy into cancer precision medicine represents a valuable asset to chemically synthesized chemicals and therapeutic antibodies. Impact Journals LLC 2017-04-27 /pmc/articles/PMC5564849/ /pubmed/28514737 http://dx.doi.org/10.18632/oncotarget.17466 Text en Copyright: © 2017 Efferth et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Review Efferth, Thomas Saeed, Mohamed E.M. Mirghani, Elhaj Alim, Awadh Yassin, Zahir Saeed, Elfatih Khalid, Hassan E. Daak, Salah Integration of phytochemicals and phytotherapy into cancer precision medicine |
title | Integration of phytochemicals and phytotherapy into cancer precision medicine |
title_full | Integration of phytochemicals and phytotherapy into cancer precision medicine |
title_fullStr | Integration of phytochemicals and phytotherapy into cancer precision medicine |
title_full_unstemmed | Integration of phytochemicals and phytotherapy into cancer precision medicine |
title_short | Integration of phytochemicals and phytotherapy into cancer precision medicine |
title_sort | integration of phytochemicals and phytotherapy into cancer precision medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564849/ https://www.ncbi.nlm.nih.gov/pubmed/28514737 http://dx.doi.org/10.18632/oncotarget.17466 |
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