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Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease

BACKGROUND: The systemic (extrapulmonary) effects and comorbidities of chronic obstructive pulmonary disease (COPD) contribute substantially to its burden. The supposed link between COPD and its systemic effects on distal organs could be due to the low-grade systemic inflammation. The aim of this st...

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Autores principales: Majewski, Sebastian, Pietrzak, Anna, Tworek, Damian, Szewczyk, Karolina, Kumor-Kisielewska, Anna, Kurmanowska, Zofia, Górski, Paweł, Zalewska-Janowska, Anna, Piotrowski, Wojciech Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565242/
https://www.ncbi.nlm.nih.gov/pubmed/28860735
http://dx.doi.org/10.2147/COPD.S141805
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author Majewski, Sebastian
Pietrzak, Anna
Tworek, Damian
Szewczyk, Karolina
Kumor-Kisielewska, Anna
Kurmanowska, Zofia
Górski, Paweł
Zalewska-Janowska, Anna
Piotrowski, Wojciech Jerzy
author_facet Majewski, Sebastian
Pietrzak, Anna
Tworek, Damian
Szewczyk, Karolina
Kumor-Kisielewska, Anna
Kurmanowska, Zofia
Górski, Paweł
Zalewska-Janowska, Anna
Piotrowski, Wojciech Jerzy
author_sort Majewski, Sebastian
collection PubMed
description BACKGROUND: The systemic (extrapulmonary) effects and comorbidities of chronic obstructive pulmonary disease (COPD) contribute substantially to its burden. The supposed link between COPD and its systemic effects on distal organs could be due to the low-grade systemic inflammation. The aim of this study was to investigate whether the systemic inflammation may influence the skin condition in COPD patients. MATERIALS AND METHODS: Forty patients with confirmed diagnosis of COPD and a control group consisting of 30 healthy smokers and 20 healthy never-smokers were studied. Transepidermal water loss, stratum corneum hydration, skin sebum content, melanin index, erythema index, and skin temperature were measured with worldwide-acknowledged biophysical measuring methods at the volar forearm of all participants using a multifunctional skin physiology monitor. Biomarkers of systemic inflammation, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), were measured in serum using commercially available enzyme-linked immunosorbent assays. RESULTS: There were significant differences between COPD patients and healthy never-smokers in skin temperature, melanin index, sebum content, and hydration level (P<0.05), but not for transepidermal water loss and erythema index. No significant difference was noted between COPD patients and smokers in any of the biophysical properties of the skin measured. The mean levels of hsCRP and IL-6 in serum were significantly higher in COPD patients and healthy smokers in comparison with healthy never-smokers. There were significant correlations between skin temperature and serum hsCRP (R=0.40; P=0.02) as well as skin temperature and serum IL-6 (R=0.49; P=0.005) in smokers. Stratum corneum hydration correlated significantly with serum TNF-α (R=0.37; P=0.01) in COPD patients. CONCLUSION: Differences noted in several skin biophysical properties and biomarkers of systemic inflammation between COPD patients, smokers, and healthy never-smokers may suggest a possible link between smoking-driven, low-grade systemic inflammation, and the overall skin condition.
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spelling pubmed-55652422017-08-31 Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease Majewski, Sebastian Pietrzak, Anna Tworek, Damian Szewczyk, Karolina Kumor-Kisielewska, Anna Kurmanowska, Zofia Górski, Paweł Zalewska-Janowska, Anna Piotrowski, Wojciech Jerzy Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: The systemic (extrapulmonary) effects and comorbidities of chronic obstructive pulmonary disease (COPD) contribute substantially to its burden. The supposed link between COPD and its systemic effects on distal organs could be due to the low-grade systemic inflammation. The aim of this study was to investigate whether the systemic inflammation may influence the skin condition in COPD patients. MATERIALS AND METHODS: Forty patients with confirmed diagnosis of COPD and a control group consisting of 30 healthy smokers and 20 healthy never-smokers were studied. Transepidermal water loss, stratum corneum hydration, skin sebum content, melanin index, erythema index, and skin temperature were measured with worldwide-acknowledged biophysical measuring methods at the volar forearm of all participants using a multifunctional skin physiology monitor. Biomarkers of systemic inflammation, including high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α), were measured in serum using commercially available enzyme-linked immunosorbent assays. RESULTS: There were significant differences between COPD patients and healthy never-smokers in skin temperature, melanin index, sebum content, and hydration level (P<0.05), but not for transepidermal water loss and erythema index. No significant difference was noted between COPD patients and smokers in any of the biophysical properties of the skin measured. The mean levels of hsCRP and IL-6 in serum were significantly higher in COPD patients and healthy smokers in comparison with healthy never-smokers. There were significant correlations between skin temperature and serum hsCRP (R=0.40; P=0.02) as well as skin temperature and serum IL-6 (R=0.49; P=0.005) in smokers. Stratum corneum hydration correlated significantly with serum TNF-α (R=0.37; P=0.01) in COPD patients. CONCLUSION: Differences noted in several skin biophysical properties and biomarkers of systemic inflammation between COPD patients, smokers, and healthy never-smokers may suggest a possible link between smoking-driven, low-grade systemic inflammation, and the overall skin condition. Dove Medical Press 2017-08-11 /pmc/articles/PMC5565242/ /pubmed/28860735 http://dx.doi.org/10.2147/COPD.S141805 Text en © 2017 Majewski et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Majewski, Sebastian
Pietrzak, Anna
Tworek, Damian
Szewczyk, Karolina
Kumor-Kisielewska, Anna
Kurmanowska, Zofia
Górski, Paweł
Zalewska-Janowska, Anna
Piotrowski, Wojciech Jerzy
Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
title Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
title_full Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
title_fullStr Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
title_full_unstemmed Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
title_short Skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
title_sort skin condition and its relationship to systemic inflammation in chronic obstructive pulmonary disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565242/
https://www.ncbi.nlm.nih.gov/pubmed/28860735
http://dx.doi.org/10.2147/COPD.S141805
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