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AB097. Conduction block of mammalian myelinated nerve by local cooling to 15–30 °C after a brief heating

BACKGROUND: This study aimed at understanding thermal effects on nerve conduction and developing new methods to produce a reversible thermal block of axonal conduction in mammalian myelinated nerves. METHODS: In 13 cats, conduction block of pudendal nerves by cooling (5–30 °C) or heating (42–54 °C)...

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Detalles Bibliográficos
Autores principales: Zhang, Zhaocun, Shi, Benkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565549/
http://dx.doi.org/10.21037/tau.2017.s097
Descripción
Sumario:BACKGROUND: This study aimed at understanding thermal effects on nerve conduction and developing new methods to produce a reversible thermal block of axonal conduction in mammalian myelinated nerves. METHODS: In 13 cats, conduction block of pudendal nerves by cooling (5–30 °C) or heating (42–54 °C) a small segment of the nerve was monitored by the urethral striated muscle contractions and increases in intraurethral pressure induced by intermittent electrical stimulation of the nerve. RESULTS: Cold block was observed at 5–15 °C while heat block occurred at 50–54 °C. Cold block was fully reversible, but only brief complete heat block was reversible. A brief reversible complete heat block at 50–54 °C significantly increased the cold block temperature to 15–30 °C. CONCLUSIONS: This study discovered a novel method to block mammalian myelinated nerves at 15–30 °C, providing the possibility to develop an implantable device to block axonal conduction and treat many chronic diseases.