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AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells

BACKGROUND: Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC). METH...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Niu, Yuanjie, Yue, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565550/
http://dx.doi.org/10.21037/tau.2017.s091
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author Wang, Yong
Niu, Yuanjie
Yue, Dan
author_facet Wang, Yong
Niu, Yuanjie
Yue, Dan
author_sort Wang, Yong
collection PubMed
description BACKGROUND: Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC). METHODS: In this study, we constructed C1QBP knockdown RCC cell line. Microarray assay was used to analyze C1QBP regulated genes. Cell adhesion and migratory was tested. RESULTS: C1QBP knockdown influenced expression of multiple genes associated with cell adhesion. Cell invasion abilities were significantly increased with increased metastasis to lung and liver in vivo. C1QBP may regulate RCC cell adhesion and invasion through influencing the p-GSK3/β-catenin/L1CAM expression. CONCLUSIONS: Overall, our study demonstrated that C1QBP could regulate RCC metastasis by regulating the GSK3/β-catenin/L1CAM signaling pathway.
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spelling pubmed-55655502017-09-01 AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells Wang, Yong Niu, Yuanjie Yue, Dan Transl Androl Urol Printed Abstracts BACKGROUND: Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC). METHODS: In this study, we constructed C1QBP knockdown RCC cell line. Microarray assay was used to analyze C1QBP regulated genes. Cell adhesion and migratory was tested. RESULTS: C1QBP knockdown influenced expression of multiple genes associated with cell adhesion. Cell invasion abilities were significantly increased with increased metastasis to lung and liver in vivo. C1QBP may regulate RCC cell adhesion and invasion through influencing the p-GSK3/β-catenin/L1CAM expression. CONCLUSIONS: Overall, our study demonstrated that C1QBP could regulate RCC metastasis by regulating the GSK3/β-catenin/L1CAM signaling pathway. AME Publishing Company 2017-08 /pmc/articles/PMC5565550/ http://dx.doi.org/10.21037/tau.2017.s091 Text en 2017 Translational Andrology and Urology. All rights reserved.
spellingShingle Printed Abstracts
Wang, Yong
Niu, Yuanjie
Yue, Dan
AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_full AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_fullStr AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_full_unstemmed AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_short AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells
title_sort ab091. c1qbp suppresses cell adhesion and metastasis of renal carcinoma cells
topic Printed Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565550/
http://dx.doi.org/10.21037/tau.2017.s091
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